341 results
To establish the efficacy of 60 mg baclofen compared to placebo in inducing a decrease in food craving, as assessed by a food craving questionnaires (G-FCQ-T) over 6 months in obese subjects.
Primary objective 1. To examine the association between the use of haloperidol and the acute changes in fastening serum glucose and QT interval in elderly patients undergoing surgery. Secondary objectives 1.To examine the association between the use…
To study the toxicity, efficacy and immunogenicity of naked DNA vaccines encoding the shuffled HPV 16 E7 gene products (TTFC-E7SH) in advanced-stage patients with squamous cell carcinoma of the anogenital or the head and reck region.
To study the influence of a prior opening wedge HTO on the results of a TKA.
The primary objective of this study is to demonstrate that the IOP-lowering efficacy of Travoprost Ophthalmic Solution, 0.004% (preserved with POLYQUAD) is noninferior to Timolol Ophthalmic Solution (0.5% or 0.25%) in pediatric glaucoma patients.
To compare the accuracy of syndesmotic reduction on an axial CT-scan postoperatively (reflecting syndesmotic malreduction) after syndesmotic positioning screws versus open reduction and fixation of the posterior malleolar fragment in AO Weber-C…
The objective of this study is to investigate the relation between tamoxifen use during COS, endoxifen levels reached during COS, and recurrence-free survival (locoregional recurrence, distant recurrence or death from any cause) when compared with…
This proposed study has three main objectives:1. To determine the feasibility of intra-marrow transplantation (IMT) of MSCs in lower risk MDS patients (a Phase I/II study):Although we have experience with application of (unrelated) MSCs and intra-…
To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.
The central question is: are the recently published treatment methods (a) cognitive behavioral therapy (CBT-ASD) (Schuurman 2011), and mindfulness based stress reduction (MBSR-ASD) (Spek 2011) effective interventions to reduce anxiety and depression…
To evelauate the clinical efficacy after 12 months using a composite outcome: absence of apical prolapse (st 0 or I), absence of bulge symptoms, and absence of reintervention in the treated vaginal compartments (apical and anterior)
- To assess the safety and tolerability of escalating single and multiple IV doses of SAR228810 in AD patients- To evaluate the pharmacokinetic properties of SAR228810 in plasma and CSF after escalating single and multiple IV doses of SAR228810 in…
To determine the efficacy and the safety of PREOB, a proprietary population of autologous bone-forming cells, in the treatment of non-infected hypotrophic non-union fractures of long bones.
The objective of the proposed study (1237.25) is to evaluate maximal treatment effect in FEV1 and SGRQ after 12-weeks treatment with two different doses of tiotropium + olodaterol FDC (5*g/ 5*g and 5*g/ 2.5*g) by comparison with placebo in patients…
The primary objectives of this study are to assess the performance of the Birmingham Hip Resurfacing in young active men with large femoral heads as measured with the Oxford Hip Score (OHS) and to evaluate the safety of this device as assessed by…
The objective of the study is to demonstrate that the creation of cardiac lesions with epicardially applied RF ablation through a minimally invasive surgical (MIS) approach plus EP ablation performed when needed at least 3 months later enhances the…
The objective of this pilot study is testing whether the supplementation of vitamins and minerals can reduce aggressive behavior and improve quality of life in people with mild intellectual disability. With sufficient results a follow-up research is…
Clinical experience with the MFT with veteran families indicate a positive result. Participants gave positive evaluations of the treatment and indicated that they learned a lot. Factors that are mentioned are:- The relationships in the family…
To determine whether the clinical results of ceramic bearings are as good as expected and to sort out which parameters are influencing the implant survival and complication rate. Efficacy can be measured and the treatment of patients with this type…
NOACs have no need for regular monitoring, this could have an effect on adherence. It is our objective to study adherence and patient satisfaction in WIPPS guided and non-WIPPS guided patients using Rivaroxaban