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Prevention of overtraining syndrome in young (elite) athletes: Development of a monitor and advanced techniques for clinical diagnosis.

The main objective of this research proposal is to 1). develop an on-line monitor for young athletes to prevent them from a systematic overload and to avoid overtraining 2) develop clinical tools to improve diagnostics of overtraining.

Study of neo adjuvant chemotherapy in large and/or lymphenode positive breast cancer (stage IIB-III pT2> 3cm). Multicentre - phase II - trial.

The main goal of neoadjuvant therapy should be a pathological complete response (pCR), because pCR more accurately predicts improved patient outcome and prolonged survival. In the present study, pathological response will be evaluated by The Miller…

The effects of four dosages of ethanol on simulated driving performance and event-related potentials

Investigating the effects of alcohol on simulated driving and the effects of alcohol on attentional processes during driving, indicated by ERPs recorded during an auditory oddball task presented during driving and non-driving.

A Phase 2, Placebo-Controlled, Randomized, Double-Blind, Parallel Arm, Dose Ranging Study to Evaluate Safety and Efficacy of Apixaban in Patients with a Recent Acute Coronary Syndrome

To evaluate the safety (bleeding) of 4 doses of apixaban as compared to placebo over a 26 week treatment period in selected subjects with recent (<=7 days) Acute Coronary Syndrome (ACS). To determine the optimal dose and regimen of apixaban…

Cortisol and Emotional Memory

In this study, the relationship between deficits within emotional memory and different typologies of psychopathy (impulsive vs. instrumental) will be examined. Furthermore, the current research concerns the influence (either positive or negative) of…

A Multi-Center, Open-Label Study of the Fully Human Anti-TNF Monoclonal Antibody Adalimumab for the Induction and Maintenance of Clinical Remission in Subjects with Moderate to Severe Crohn's Disease.

Investigating the safety of adalimumab when administered in subjects with Crohn*s Disease as well as evaulating the efficacy of adalimumab for the induction and maintenance of clinical remission and fistula closure in subjects with moderate to…

ADAMTS-13 levels in patients with a history of thrombotic thrombocytopenic purpura.

Purpose: Determine the ADAMTS-13 activity in patients with a history of TTP.

Volar or dorsal approach for the proximal row carpectomy: a randomized clinical multi-centre trial

Evaluation of the approach, both volar and dorsal: By means of function of the wrist, pain scores, complications and extra surgery.

Long term biomonitoring and risk assessment of decabromodiphenylether (DBDE) in humans

- Validation of the distribution of DBDE in human blood - Screening of 4 different European countries on DBDE in human blood - to collect human blood samples over a period of ten years from 80 subjects over a 10 year period to establish a long term…

Molecular mechanisms in the host-pathogen interaction in neonates; an approach on the level of gene and protein expression

To investigate the gene and protein expression of neonates suffering from CoNS late-onset sepsis.

Neuroprotection in Aneurysmal Subarachnoid Hemorrhage - from Laboratory to Clinical Practice

Delayed cerebral ischemia (DCI) is an important cause of death and dependence after SAH. Vasospasm plays an important role in the pathogenesis of DCI, because many patients have constricted arteries during the period of DCI, but vasospasm is not a…