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MR Imaging of Lymphadenopathy in Rectal Cancer using the MR Agent Vasovist

Primary objective• To validate the potential of Vasovist®-enhanced MRI for accurate prediction of nodal status in patients with primary rectal cancer using histopathological examination after surgery as the SOR.Secondary objectives• To compare the…

A Randomized, Phase 3, Open-Label Study of Combinations of REGN2810 (Anti-PD-1 Antibody), Platinum based Doublet Chemotherapy, and Ipilimumab (Anti-CTLA-4 Antibody) Versus Pembrolizumab Monotherapy in First-Line Treatment of Patients With Advanced or Metastatic Non-Small Cell Lung Cancer With Tumors Expressing PD-L1 >=50%

The primary objective of the study is to compare the progression-free survival (PFS) of REGN2810 (cemiplimab) plus ipilimumab combination therapy (hereinafter referred to as REGN2810/ipi) and REGN2810 plus 2 cycles only of platinum-based doublet…

COVID-19: addition of azithromycin to chloroquine treatment

Primary objective:Does addition of azithromycin to standard chloroquine treatment result in a higher clinical cure rate at day 7 than treatment with chloroquine alone in patients with COVID-19.Cure is considered when 4 criteria are present:(1) O2…

Convalescent Antibody-Mediated Treatment of COVID-19 Infections in Patients with B-cell dysfunction, a Randomized Trial (COVID-Compromise Study).

There have been reports of a more serious course of COVID-19 infections in patients with a reduced immune system, such as patients with congenital immune disorders, (haematological) malignancies or patients taking medications that suppress the…

Pivotal Study Of A Dual Epicardial & Endocardial Procedure (DEEP) Approach for Treatment of Subjects with Persistent or Long Standing Persistent Atrial Fibrillation with Radiofrequency Ablation

The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presentingwith Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation utilizing the…

Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP (OPTIC trial)

Primary objective of this randomized controlled trial is to assess whether combining IVIg and IVMP leads to more frequent long-term remission in CIDP compared to treatment with IVIg alone. Main secondary objectives are to assess whether IVIg and…

Blood-borne assessment of stromal activation in esophageal
adenocarcinoma to guide tocilizumab therapy: a randomized
phase II proof-of-concept study

This study has been transitioned to CTIS with ID 2023-509458-77-00 check the CTIS register for the current data. The primary objective of the study of this study is to demonstrate that stroma-targeting by tocilizumab in esophageal adenocarcinoma…