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Transcranial magnetic stimulation (TMS) to slow down cognitive decline in Alzheimer*s disease (AD): TMSLA - a monocentric randomized controlled trial.

The main objective is to replicate the results of the recent successful efficacy study on precuneus rTMS in AD by Koch et al. (2022). Secondary objectives include investigating what functional brain activity/network changes underlie the effects of…

Restorative Deepfake Intervention Netherlands (REDEFINE):
Deepfake survivor-perpetrator confrontation for young adults with sexual violence-related PTSD

To evaluate the acceptability and effectiveness of a deepfake victim-perpetrator confrontation in young adults with sexual violence-related PTSD.

Efficacy and safety of minidosing lysergic acid diethylamide (LSD) for chronic cluster headache: a
randomized placebo-controlled study

This study has been transitioned to CTIS with ID 2024-520305-39-00 check the CTIS register for the current data. Primary objective: to evaluate the efficacy of LSD 25µg every 3 days for 3 weeks in cCH. Additional objectives:- To evaluate the safety…

Using Diffuse Reflectance Spectroscopy Probes to conduct Optical Measurements during Surgery for Colorectal Cancer

To assess the practical usability of our DRS probes for the detection of positive resection margins in colorectal cancer surgery - specifically whether they can be used in the confined surgical workfield in the lower pelvis - as well as the…

Home-based management of hypoxemic patients with acute respiratory tract infections. A complex intervention study with a randomized controlled trial embedded in a regional collaborative healthcare network.

The main objective of this study is to assess the feasibility, safety and (cost-)effectiveness of the HOME-ART intervention in comparison to regular hospital admission in patients with CA-ARTI.

Trial NL87938.000.24

Publication withdrawn by sponsor

Adaptive anastomosis for anterior resection in sigmoid and proximal rectal cancer or premalignant lesions: a multicentre non-randomised clinical effectiveness trial (ADAPT)

The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…

OMIT trial: omitting therapeutic lymph node dissection in patients with stage IIIB/C melanoma and major pathological response in the index lymph node after neoadjudvant immunotherapy

To investigate whether TLND can be safely omitted in patients with macroscopic resectable stage III (B/C/D) melanoma achieving an MPR within the ILN upon neoadjuvant treatment with nivolumab in combination with ipilimumab.