2878 results
Possibly, outcomes of treatment can be further improved by adding atezolizumab to neoadjuvant chemoradiation. As a first step we aim to know whether the addition of atezolizumab feasible. That is, we want to know how the treatment is tolerated and…
Primary:• To evaluate the safety of ORGN001 (formerly ALXN1101) over the first 6 months of treatmentSecondary:• To characterize the pharmacokinetics (PK) of increasing doses of ORGN001 (formerly ALXN1101) • To evaluate the effect of ORGN001 (…
The aim of the study is to investigate whether inhibition of the left or right insula has differential effects with regard to clinical outcomes (i.e. smoking cessation/reduction), cognitive processes (i.e. cognitive control, craving and goal-…
To evaluate the acceptability and effectiveness of a deepfake victim-perpetrator confrontation in young adults with sexual violence-related PTSD.
This study has been transitioned to CTIS with ID 2024-520305-39-00 check the CTIS register for the current data. Primary objective: to evaluate the efficacy of LSD 25µg every 3 days for 3 weeks in cCH. Additional objectives:- To evaluate the safety…
In this trial, the researchers want to know how safe AZD8630 is and how well it works to control asthma symptoms when taken with the Saphira inhaler alongside their standard medication. Saphira is a new device that has been designed to deliver…
Primary: Can the number of online adaptive fractions be reduced by 30%?Secondary: What is the overall survival, local control, and toxicity? What is the movement of the bowel during treatment? Is there added value in re-aligning the patient when…
The first part of the study aims to depict speech and swallowing function with 3D-dMRI in healthy volunteers to establish a set protocol for use in patients. The second part of the study will investigate if anatomical and functional differences in…
The PAPBI-3 trial is a phase I/II interventional trial assessing the toxicity and feasibility of repeat breast conserving therapy with preoperative partial breast irradiation in female patients aged 51 years or older with ipsilateral recurrent or…
This study has been transitioned to CTIS with ID 2024-515885-15-00 check the CTIS register for the current data. Main objectives:• To evaluate whole body distribution of 89Zr-Df-crefmirlimab in cancer patients prior to and during treatment with an…
This study has been transitioned to CTIS with ID 2024-514266-39-00 check the CTIS register for the current data. Phase 1 Primary Objective(s):-to evaluate the overall safety and tolerability of NVL-655-to determine the RP2D and, if applicable, the…
The aim of the study is to investigate the effect of MDRT to the visible lesions in patients with omCRPC (up to 3 metastases and/or local recurrence) while continuing the ongoing systemic treatment. Progression is based on prostate specific membrane…
This randomized phase II open label study examines the effect of controlled cooling versus no cooling on the incidence and severity of oxaliplatin-induced peripheral neuropathy (OIPN) in patients treated with oxaliplatin.
To determine safety, tolerability, and activity of individualized radioembolization with 166Ho-microspheres combined with FTD-TPI and bevacizumab.
Primary Objective: • To assess whether the food supplement Endocalyx lowers blood pressure in patients with treatment resistant hypertension.Secondary Objectives: • To study the effect of Endocalyx on office blood pressure and 24-hour blood pressure…
The main objectives are to investigate whether our product is suitable for the target group, to identify barriers to wider implementation in mainstream care, and to gather patient experience and feedback. We want to know if patients perceive the…
To study the impact of tVNS on gut motor function, in particular with regards to its potential to induce phase III contractions in the upper GI tract, in healthy subjects.
The primary objective of this study is to compare efficacy of IRE to the efficacy of SBRT regarding the primary endpoint (local control at 2 years) in patients with perivascular and peribiliary CRLM (0-5 cm). The CRLM are unsuitable for surgery and…
The main objective is to investigate the effect of a 16-week AET or CBT program on fatigue in patients with MG, compared to care as usual.
The primary goal is to demonstrate that in gastric esophageal cancer the addition of a microbiome intervention with fecal capsules from healthy donors can improve the effectiveness of perioperative chemotherapy as measured by the tumor regression…