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A Long-Term Follow-Up Study of Subjects Who Participated in a Clinical Trial in which
Peginterferon Lambda 1-a (BMS-914143) was Administered for the Treatment of Chronic Hepatitis C

Recent studies demonstrate long-term durability of virologic response with pegylated alpha-interferon-based therapies. Comparable information is not yet available for Lambda or for regimens combining lambda interferons, RBV, and DAAs. In this…

Eeva* Pregnancy Investigational Clinical Study (EPIC): A Post-Market Follow-Up Study.

The main objective is to compare the rate of clinical pregnancy at approximately 5-8 weeks gestational age for the Day 3 embryo transfers that used Eeva predictions with morphology grading to that for Day 3 embryo transfers using morphology grading…

Knee joint replacement over 5 years in patients with knee osteoarthritis. A long term follow up study in patients of the CL3-12911-018 study.

To collect data on knee joint replacement procedures or procedurespracticed in the knee (arthroscopy, osteotomy or other) over 5 years inpatients with knee osteoarthritis having participated in the CL3-12911-018 study and having received at least…

A Modified Case Control Study To Identify Pharmacogenomic Factors Associated With Hepatocellular Injury Following Exposure To Lapaquistat Acetate

To examine the genetic contribution to the mechanism of lapaquistat acetate induced hepatic abnormalities.

Intervention pilot study with FFP or the combination of fibrinogen concentrate and FFP to patients with massive (post) operative bloodloss.

In this study we will try to obtain the rise in value of fibrinogen concentrate infusion in combination with FFP vs FFP transfusion in surgery patients with massive peri-operative bleeding problems and cardiothoracic surgery patients after heart…

A PHASE 3, MULTI-SITE, OPEN-LABEL STUDY OF THE LONG TERM SAFETY AND TOLERABILITY OF 2 ORAL DOSES OF CP-690,550 IN SUBJECTS WITH MODERATE TO SEVERE CHRONIC PLAQUE PSORIASIS

Primary Objective- To evaluate the long term safety and tolerability of treatment with CP-690,550 (10 mg BID or variable dose 5 and 10 mg BID) in adult subjects with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy…

A 24-week randomized, controlled, multicenter, open-label study to evaluate the effect of reminder notifications and motivational/adaptive messaging on treatment adherence of COPD
subjects receiving Ultibro® Breezhaler® treatment using the Concept2 inhaler for dose administration and tracking

This study will evaluate the effect of dose tracking in conjunction with reminder notificationsand motivational/adaptive messages over 24 weeks on treatment adherence behavior insubjects with COPD. The dose tracking is done by the Concept2 inhaler…

Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: alternative versus standard stimulation protocols; the STIM-trial

To evaluate the effects of COS with tamoxifen or letrozole compared to standard COS, on oocytes retrieved.

A multi-center, prospective, randomized, double-blind study to assess the impact of sacubitril/valsartan vs. enalapril on daily physical activity using a wrist worn actigraphy device in adult chronic heart failure patients

Primary:- To elucidate the change in physical activity as assessed by the distance walked in meters during the 6-minute walk test between baseline and 12weeks of study drug treatment in sacubitril/valsartan vs. enalapril patients.- To assess changes…

Clinical Performance Study Plan for Ki-67 IHC MIB-1 pharmDx (Dako Omnis) on Early Breast Cancer Specimens used to identify subjects for enrolment in AstraZeneca*s Phase III CAMBRIA-1 trial (D8531C00002)

This clinical performance study will evaluate the effectiveness of the Ki 67 IHC MIB-1 pharmDx (Dako Omnis) to identify estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)- early breast cancer patients whose tumours score Ki-67…