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Preventing contrAst induced Nephropathy after TranscathEter aortic valve Replacement

To evaluate the efficacy of 250ml 1.4% sodium bicarbonate versus hypotone saline hydration prior to TAVI in patients with CKD to prevent CIN.

Infection prevention and immune modulation by bacterial lysates in patients with asthma: gaining insight into the mechanism of an old therapy

To diminish the number of asthma exacerbations with the regular use of a bacterial lysate.

Pharmacokinetics of posaconazole (Noxafil(R)) as prophylaxis for invasive fungal disease

• To determine the pharmacokinetics of posaconazole (new solid oral and IV) given as prophylaxis to patients who are at risk for developing fungal infections after receiving conditioning therapy (except strictly non myeloablative (NMA)) for…

The antibody response to pneumococcal vaccination in patients
with inflammatory bowel disease patients treated with immunosuppressive agents

Primary objective: to determine the vaccine efficacy of PCV13 plus PPV23 (2-month series) in cases, i.e. IBD patients treated with immunosuppressive agents, vs controls. Secondary objectives: - To assess if the use of a TNF-alpha inhibitor affects…

Home Treatment of Patients with Low-Risk Pulmonary Embolism with the Oral Factor Xa Inhibitor Rivaroxaban: Prospective Management Trial (HoT-PE)

Objective of the study: Primary objective: to determine whether early discharge and out-of-hospital treatment of patients with low-risk acute PE (as defined by the inclusion and exclusion criteria) with the new oral factor Xa inhibitor rivaroxaban…

Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy.

This study is designed to provide evidence regarding the prophylactic use of UDCA in preventing symptomatic gallstone disease after RYGB and Sleeve Gastrectomy.

The predictive value of the acute effect of beclomethasone-dipropionate on an exercise-challenge test for the outcome of longterm treatment with beclomethasone-dipropionate in childhood asthma.

This study aims to investigate if there is a correlation between the severity of bronchoconstriction after an exercise challenge test 6h after a single dose of Qvar and after 4 weeks of treatment with Qvar, in order to know if the respons to a…

A randomized controlled trial comparing venous stenting with conservative treatment in patients with Deep Venous Obstruction

Primary Objective: Measure QoL (VEINES QoL/Sym) change in patients with DVO at one year after PTA and stenting compared to conventional therapy (short class II elastic compressions stockings, exercise, lymph drainage therapy and the use of (pain)…

Randomized, Placebo-Controlled, Double-Blind, Multicenter Study to Determine the Efficacy and Safety of Vedolizumab in Prevention of Endoscopic Recurrence of Crohn's Disease in Patients with Ileo-colonic Surgical Resection and Ileocolonic Anastamosis : REPREVIO (recurrence prevention with Entyvio)

The primary objective of this prospective placebo-controlled study is to assess the ability of vedolizumab to prevent postoperative endoscopic recurrence of Crohn*s disease in the neoterminal ileum.