Search for a trial

Randomized trial of Legflow® Paclitaxel eluting balloon (LPEB) with stentplacement vs. standard PTA with stentplacement for the treatment of intermediate (>5 cm and < 15 cm) and long (>15 cm) lesions of the superficial femoral artery (SFA). The RAPID trial.

The primary objective is to assess the difference in absence of binary restenosis rate of endovascular treatment of intermediate and long lesions of the superficial femoral artery with the Legflow® PEB and nitinol stent, when compared to uncoated…

Diarrhea during use of the oral angiogenesis inhibitors sunitinib and sorafenib

To identify what might be the cause of the occurrence of diarrhea during the use of angiogenesis inhibitors sunitinib and sorafenib in patients with a malignancy.

An Open-Label, Multi-Center, Follow-Up Study Designed to Evaluate the Long-Term Effects of Rasagiline in Parkinson's Disease Subjects who Participated in the ADAGIO Study

- To investigate whether the effect of early-start rasagiline treatment (according to the ADAGIO study protocol) provided long term benefits over delayed-start.- To investigate the long-term effects of rasagiline in PD subjects who participated in…

Natural course, effects of enzyme therapy and health economic aspects in patients with mucopolysaccharidosis type I, II and VI. Long-term folloe-up of untreated patients and patients receiving commercially available Aldurazyme, Elaprase and Naglazyme.

the objective of the current study is to evaluate the safety and efficacy of enzyme therapy in the Dutch population of patients with MPS I, II and VI; to compare this to the natural course of these diseases; to make an inventory of the direct and…

Measuring the effects of continuous dopaminergic stimulation on nocturnal movements in Parkinson's disease.

Primary:• To study the effect of rotigotine on nocturnal hypokinesiaSecondary:• To study the possibility of measuring nocturnal hypokinesia and its severity in a home setting• To correlate improvements in sleep quality by rotigotine with changes in…

MIBG scintigraphy and Strain Echocardiography in the early detection of late cardiovascular effects of (neo)adjuvant breast cancer treatment with docetaxel, doxorubicin and cyclophosphamide (TAC): a pilot study

1. To detect subclinical cardiovascular damage in adults patients with breast cancer who have completed treatment with TAC at least one year previously at least one year previously, using MIBG scintigraphy, novel echocardiographic techniques and…

"PSOGEN:Effect adalimumab op zelfbeeld en seksueel functioneren bij matige en ernstige psoriasis van de anogenitale regio; prospectief, open label pilot onderzoek"

The objective is to assess the effect of adalimumab on selfconfidence and sexuality of patients with anogenital psoriasis.

Evaluation of cognitive function of patients treated with sunitinib or sorafenib (UMCONCO200904

Tot evaluate the cognitive function of patients treated with sunitinib or sorafenib for metastatic renal cell cancer or a GIST, in order to get more insight in the prevalence, typeand etiology of cognitive dysfunctioning during treatment with…

het optimaliseren van de voorbereiding voor sigmoidoscopie in de regio; Moviprep versus Bisacodyl/klysma, een enkelblind gerandomiseerd onderzoek

-

HPV testing and the long term risk at cervical disease

The primary objectives of our study are: - Determining the long-term predictive value of a positive HPV test for (pre)malignant cervical disease.- Determining the long-term protective value of a negative HPV test. - Determining the long-term…

Vestibulotoxicity in consequence of tobramycin therapy in cystic fibrosis patients

Primary objective: to investigate the prevalence of vestibulotoxicity and disturbance of equilibrium as far a Cystic Fibrosis patients with at least one treatment with tobramycin are concerned. Secondary objective: To formulate an advice for…

a retrospective longitudinal clinical cohort study to investigate HPV testing post-treatment and the risk of recurrence of (cervical) disease on the long term.

The primary objective is to determine the positive and negative predictive value of an hrHPV test after treatment for the development of recurrent (cervical) disease on the long term.

Pilot study: Is concomitant administration of lidocaine during oxaliplatin infusion able to prevent pain as a result of oxaliplatin induced acute neuropathy?

Primary objectiveTo evaluate the efficacy of low dose intravenously lidocaine in comparison with placebo in terms of pain relief after the first oxaliplatin administration measured by a numeric rating scale (NRS 0-10).Secondary objectives1.…

INSIDE-LRP: Non-Invasive Identification with Computed Tomography Coronary Angiography of Vulnerable Lipid-Rich Plaques

To develop a non-invasive algorithm that allows the detection of LRPs with CTCA

Oil- based versus water-based contrast media for hysterosalpingography (HSG) in infertile women with unevaluated indications: a randomized controlled trial

This study has been transitioned to CTIS with ID 2024-512571-12-00 check the CTIS register for the current data. The objective of the proposed study is to assess the effectiveness and cost-effectiveness of the use of oil versus water-based contrast…

MONOPOLY: predicting clinical benefit of dupilumab in adult patients with chronic rhinosinusitis with nasal polyps (CRSwNP)

Primary objective: to identify predicting phenotypical and endotypical biomarkers for the response to dupilumab in adult patients with CRSwNP, by comparing the type 2 inflammation in the peripheral blood and nasal polyp tissue at baseline and after…

The effect of extra hydration on kidney function during carboplatin-pemetrexed-pembrolizumab in patients with advanced non-small cell lung cancer.;*Hydration to prevent nephrotoxicity due to pemetrexed (HydraPem Study)*

To investigate the effect of fluid infusion to prevent deterioration of kidney function due to pemetrexed, during treatment with carboplatin, pemetrexed and pembrolizumab in patients with non-squamous NSCLC. The primary objective is to reduce the…

Molecular Markers in the Treatment of Endometrial Cancer 2

Primary objectives:MoMaTEC2 aims to test the applicability of already identified and promising molecular biomarkers ER and PR, to improve risk stratification and individualisation of treatment for patients with EC.Secondary objectives:To perform a…

A Stratification trial to determine key immunological factors predicting Tofacitinib efficacy in Psoriatic Arthritis (PsA). TOFA-PREDICT

This study has been transitioned to CTIS with ID 2024-510903-12-00 check the CTIS register for the current data. Primary objective:Identify pre-treatment profiles with integrated clinical, transcriptomic, metabolomic, proteomic, flow cytometric, and…

European microCirculatory Resistance and Absolute Flow Team-The Euro-CRAFT Registry
Prospective evaluation of the impact of coronary themodilution on clinical outcomes in chronic coronary syndromes

To assess the rate of major adverse cardiac and cerebrovascular events (MACCE) between patients with and without coronary microvascular disease (CMD) based on Microvascular Resistance Reserve (MRR) at 1 year follow-up.