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Biomedical interventions for HIV prevention in MSM in Amsterdam: a demonstration project

The objective of this project is to investigate uptake, usability and acceptability of two hiv prevention interventions. These relate to the use of biomedical interventions, ie the provision of daily and intermittent PrEP to men who have sex with…

Implementation of a strategy of osteoporosis screening in patients over 50 years of age with a first fracture, with intensive treatment and follow-up by a nurse-practitioner to prevent recurrent fractures in those patients with diagnosed osteoporosis

Is it possible to improve routine detection and treatment of osteoporosis after an initial fracture?I) is it possible to increase the proportion of patients adequately screened and categorized as to the presence of osteoporosis from current practice…

Consortium for the Lifespan Examination of ADHD Registry (CLEAR)
Study: An International, Longitudinal, Observational Study of
Individuals with Attention-Deficit/Hyperactivity Disorder (ADHD)

The overall objectives of CLEAR are to improve our global understanding of the longitudinal impact ofattention-deficit/hyperactivity disorder (ADHD) and contribute to the body of scientific evidence regarding thetreatment and evolution of ADHD over…

Ambulation performance in chronic stroke patients using an implanted drop foot stimulator

The aim is to convince the rehabilitation community that drop foot after stroke can be functionallycorrected which increases significantly quality of life. The information will be spread throughrehabilitation centers targetting rehab physicians,…

Postpartum care 2.0: do flexible distribution and intermission of postpartum care, without extension of hours, have a positive effect on the success rate of breastfeeding, experienced empowerment and quality of care by the mother during and after postpartum period?

The aim of this reseach project is to gain insights into the effects of distribution and intermission of postpartum care hours on the success rate of breastfeeding and the experienced empowerment and quality of care by the mother during and after…

Implementation and effect of exercise and respiratory training on 6-minute walking distance in patients with severe chronic pulmonary hypertension: a randomized controlled multicenter trial in European countries

The aim of this study is to guide European PH-centers to become specialized centers for training in PH. This approach is in line with European PH-guidelines [12] which classified the exercise training in specialized centers with a closely monitored…

Impact of new approaches to pharmacological management of patients with renal cell carcinoma: a population-based study of process and outcomes in The Netherlands

The 1st main objective is to collect detailed quantitative data on the everyday management of mRCC in the Netherlands, the clinical outcome of this management, as well as the resulting quality of life and financial costs. Treatment selection for…

Open Label Randomise Controlled Trial to the efficiency of oral nutrition supplementation during medical rounds in malnourised patients in the Netherlands

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Stichting Gezondheidscentra Eindhoven (SGE) Smoking Cessation Innovation.

Our proposed randomized controlled trial is the first making this head-to-head comparison in a *real life* primary care setting in the Netherlands. The primary research question is: does a 12-week combination therapy of open label varenicline and…

Cost-effectiveness of CYP2C19 genotype guided treatment with antipaletelet drugs in patients with ST-segment-elevation myocardial infarction undergoing immediate percutaneous coronary intervention with stent implantation: optimization of treatment.

To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.

Non-invasive rapid assessment of non-alcoholic fatty liver
disease (NAFLD) using Magnetic Resonance Imaging with LiverMultiScan (RADIcAL)

Primary objective: To investigate whether the introduction of LiverMultiScan as a standardised diagnostic test for liver disease can prove a cost effective method in different EU territories.Secondary Objectives:- To investigate patient satisfaction…

Multicentre, Open-label, Randomised Study to Assess the Diagnostic Value of Amyloid PET
Imaging in Patients with Subjective Cognitive Decline Plus, Mild Cognitive Impairment, or Dementia
Where Alzheimer*s Disease Is in the Differential Diagnosis (Diagnostic and Patient Management
Study)

This study (AMYPAD Diagnostic and Patient Management Study) will determine in a real-life clinical setting for whom diagnostic amyloid PET imaging is appropriate, when this is best performed, and how the resulting information is influencing…

Ticagrelor or prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome and a high bleeding risk: optimization of antiplatelet treatment in high-risk elderly

To assess the safety, efficacy and net clinical benefit of clopidogrel versus the new antiplatelet drugs i.e. ticagrelor and prasugrel in patients older than 70 years.

Effect of a bundle of non-pharmacological interventions on the stress response to surgery

To assess the effect of a bundle of non-pharmacological interventions implemented in the post-anesthesia care unit on the total serum cortisol levels after intermediate and major surgery.