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The effects of anaesthesia on neurodevelopmental outcome and apnoe in infants: the GAS study.

The primary objective of this trial is to determine whether different types of anaesthesia [regional versus general] given to infants undergoing inguinal hernia repair result in equivalent neurodevelopmental outcomes. Secondary objectives are to…

Study to determine the appropriate age for a second immunization with the Meningococcal C conjugated vaccine.

The main purpose of this study is to determine the appropriate age (10, 12 or 15 years) for a second MenC conjugate (MenCC) vaccine immunization in Dutch children that received a primary MenCC vaccination at a young age. A conclusion will be based…

An Open-Label Study of the Safety and Efficacy of ReFacto AF in Previously Untreated Patients in Usual Care Settings

The primary objective is to evaluate the safety of ReFacto AF in previously untreated patients (no prior exposure to factor products or any blood products) of less than 6 years of age.

Predictive value of baseline and stimulated serum IGF-1 and IGFBP-3 during a dose-escalation IGF-1 generation test with NutropinAq for the 1 year growth response to growth hormone (GH) therapy in short children with low IGF-1 and a normal GH peak in a provocation test

Primary objective: Assessment of the value of the short-term (2 weeks) response of IGF-I (peak IGF-I SDS) to GH in a dosage of 1.4 mg/m2/day (as part of a dose-escalation IGF-I generation test) in comparison to baseline IGF-I to predict the 1 year…

Vincristine and concomitant azole therapy in pediatric acute lymphoblastic leukemia patients - a pharmacokinetic study

Primary objective:To assess vincristine pharmacokinetics during concomitant azole therapy, which is given in the context of standard treatment (hence this concerns an observational and not an intervention study)Secondary objectives:- To evaluate the…

Conservative treatment of simple forearm fractures, cast versus elastic bandage (tubigrip)

What is the function of the forearm after a torus fracture in children at an age of 4 to 10 with different immobilisation techniquesWhat is the time that children after a torus fracture are using their limb, without making use of a form of…

International Second Immunoglobulin Dose in Guillain-Barre Syndrome patients with poor prognosis.

Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…

A randomised clinical trial on the effectiveness of Emla and Rapydan for prevention of vena punction-induced pain in children.

To study whether a novel plaster (Rapydan) is more successfull in diminishing pain/ discomfort than the usual plaster (EMLA).

Development of humoral and cellular immune response in infants after pneumococcal conjugate vaccinations with Synflorix® or Prevenar-13®

Primary: To compare immunogenicity (humoral and cellular) induced by PCV10 and PCV13 after the booster dose of a complete vaccination series (3+1, the current NIP schedule) Secondary: To compare immunogenicity (humoral) induced by PCV10 and PCV13 at…