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Personalized elective neck irradiation guided by sentinel lymph node biopsy in patients with squamous cell carcinoma of the oropharynx, larynx or hypopharynx with a clinically negative neck: (chemo)radiotherapy to the PRIMary tumor Only. The PRIMO study.

To compare safety and efficacy of treatment with sentinel lymph node biopsy guided elective neck irradiation versus standard elective neck irradiation in patients receiving definitive (chemo)radiotherapy for squamous cell carcinoma of the…

A prospective, randomized study comparing chemotherapy versus chemotherapy plus immunotherapy in patients with advanced non-small cell lung cancer with low TMB and oncogenic driver, STK11, KEAP1 or NFE2L2 mutation and a PD-L1 TPS

To compare the objective response rate between patients with metastatic non-small cell lung cancer characterized by PDL-1 TPS<50% and low TMB and either actionable mutation, inactivating STK11, KEAP1 or NFE2L2 mutations, treated by…

Understanding colchicine resistance in Familial Mediterranean Fever; exploring pathophysiological mechanisms and therapeutic options

The primary objective is to identify what causes colchicine resistance in FMF. Additionally, we will try to identify potential interventions to overcome resistance

COBRA re-KAI study: research into the immune response of COVID-19 revaccination after stem cell transplant or B-cel depleting immuno(chemo)therapy.

To answer the following questions: 1. Who are the patients that need to be revaccinated?2. How many vaccinations are needed to restore SARS-CoV-2 immunity?3. Can the number of vaccinations needed to restore SARS-CoV-2 immunity be predicted?To…

Model Informed preciSion doSIng tO iNdividualise and optimize pharmacotherapeutic treatment (MISSION) - Appendix 1: Prospective evaluation of Model informed precision dosing (MIPD) for tacrolimus and mycophenolic acid in paediatric patients with a kidney disease

Overall objective:To improve the existing drug prescribing and treatment monitoring process.Objective appendix 1: To prospectively evaluate the predictive performance of the MIPD strategy for tacrolimus and mycophenolic acid in paediatric patients…

Home-based exergaming for enhancing resistance to falls after stroke (HEROES): Proof-of-principle evaluation.

This proof-of-principle evaluation aims to investigate whether a home-based balance training using an exergame (HEROES), following a single session of perturbation-based training improves reactive step quality in people with chronic stroke.

Check@Home: General population screening for early detection of atrial fibrillation and
chronic kidney disease

The Check@Home consortium aims to set up a roadmap and infrastructure for a (cost-)effective program to early detect atrial fibrillation and chronic kidney disease (defined by elevated albuminuria) in the general population. Furthermore, the…

Analysing cEllular bioenergetics aNd structural aDaptations in the qUadriceps muscle befoRe and After endobroNChial valve treatmEnt.

To investigate the physiological and structural adaptations of peripheral muscle function at a cellular level in response to EBV treatment.

PRophylactic cerebral Irradiation or active MAgnetic resonance imaging surveillance in small-cell Lung cancer patients

The primary objective is to show that brain MRI surveillance alone is non-inferior in terms of overall survival (OS) to brain MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema: The CONVERT II Trial

This study is to investigate the safety and effectiveness of the AeriSeal system in limiting collateral ventilation within a target lung lobe. And to achieve lung volume reduction using Zephyur Vavles and assess lung function, hyperinflations and…

SEAL - Safety & Feasibility Evaluation of the Aortoseal Endostapling System for seal and fixation of abdominal aortic aneurysms (AAA) endovascular grafts to the aortic wall

The objective of the SEAL Early Feasibility Study (STUDY) is to provide proof of concept and initialclinical safety data for the Aortoseal Endostapling System for the fixation and seal of abdominal aorticaneurysms (AAA) endovascular grafts to the…