105 results
To generate a large, international Friedreich*s ataxia patient database (including healthy controls), alongside an integrated clinical and natural history database, which is linked to a biological samples and imaging repository, hereby creating a…
This study aims to determine the effect of real-time symptom monitoring on HRQoL in patients with mBC who start first-line chemo(immune)therapy. Further objectives include analyzing the effect of PRS monitoring on physical functioning, the severity…
The general aim of this project is to determine the (cost-)effectiveness of footwear modification in addition to GP-led usual care, compared to GP-led usual care alone for patients with first MTP joint osteoarthritis (OA) at 6 months of follow-up…
The primary objective is to show that brain MRI surveillance alone is non-inferior in terms of overall survival (OS) to brain MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).
In this research, we are comparing two distinct physiotherapy treatments as post-operative care following shoulder arthroscopy (Bankart repair). Our aim is to gain a better understanding of how to provide optimal post-operative care for patients…
Unravelling the *measles paradox* by in-depth characterization of the immune repertoire before and after natural measles or measles vaccination.
We aim to characterize innate anti-viral defence responses in the upper airways of COPD patients.
To identify the effect of psoriasis and the treatment with biologics on the pre-pregnancy uterine immune environment of psoriasis patients.
Objective 1: To assess the effect of implementation of a dashboard, with (near) real-time data feedback of risk stratification tools and care processes, on relevant clinical outcomes (in-hospital mortality, ED-LOS, admission rate) and discrepancy…
Primary Objective: To investigate the change of objectively measured physical activity over time, from preoperative, to being placed on the waiting list for cardiac surgery, to postoperative. Secondary Objective(s): To…
The aim of this study is to objectively determine physical activity levels and to explore factors associated with the level of physical activity during hospital admission in hospitalized children between six months and 18 years old.
The primary aim of this study is to investigate the effect of four different degrees of arch support on arch compression and running economy. Moreover, as a secondary aim, this study also examines the effect of bending location on running economy.…
To assess the association between time-in-range blood pressure measurements and the risk of developing preeclampsia in women with hypertensive disorders of pregnancy. To evaluate the relationship between time-in-range blood pressure and gestational…
This research's goal is to develop an artificial intelligence (AI) model that can predict when a child is at risk of experiencing an asthma exacerbation and what their personal risk factors are. The model should be both accurate and…
How do middle-aged people in the northern Netherlands, both with and without a migration background, prepare for aging, and what support do they need?
Máxima MC is organising this study. The aim of the study is to gain insight into the effect ofdifferent treatments (medication, IUD, endometrial ablation, uterus removal) formenstruation-related complaints on labour and educational participation.…
The objective is to investigate if AHCL in children with DM1 leads to a greater difference in BMI SDS compared to MDI. The second objective is to study if there is a difference between MDI and AHCL in DM1 regarding blood glucose regulation and…
The primary objective of this research is to assess the occurrence, variability and underlying causes of treating pediatric patients with respiratory infections at the ED. This is done in order to identify and ultimately de-implement ineffective…
The purpose of this protocol amendment is to meet the current and future needs of the MacTel Project’s collaborating investigators and continue meeting initial objectives. In addition, a third objective is to understand the mechanisms involved in…
The primary objective of this study is to evaluate the added value of PSMA PET/CT and PSMA-targeted biopsies of PSMA-avid lesions in detecting ISUP GG ≥ 2 prostate cancer in patients with a negative or equivocal MRI (PIRADS 1-3) and a PSA density…