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Safety and Tolerability of Nebulized Amoxicillin-Clavulanic Acid in Patients with COPD.

Approved WMORecruitment stopped

To investigate the safety and tolerability of inhalation of nebulized amoxicillin clavulanic acid in stable COPD patients.Secondary Objective(s): To investigate the amoxicillin levels obtained in sputum and serum

Amoxicillin-clavulanic acid Levels in Sputum After Nebulization in AECOPD (ALSAN)

Approved WMOPending

In this study we want to show adequate sputum levels are obtained throughout the day after inhalation of nebulized amoxicillin clavulanic acid in hospitalized AECOPD patients.