Search for a trial

A dose-ascending, parallel group, randomised, double-blind, placebo-controlled pilot phase followed by a parallel group, randomised, double-blind, placebo-controlled phase to compare the effect of intravenous MR30507/09, MR30365/07 and fentanyl on respiratory responses, and an assessment of naloxone reversal and naltrexone blockade on MR30507/09 and MR30365/07 in healthy subjects

This study is intended to establish a dose response rate of MR30507/09 with respect to respiratory effects compared to MR30365/07, fentanyl and placebo..

A MR30365/07 dose-ascending, cohort group, single-blind pilot phase followed by a randomised, double-blind, placebo controlled parallel group study to compare the effect of intravenous MR30365/07 and intravenous fentanyl on respiration and analgesic responses, in healthy volunteers.

The aim of the main study is to compare the effects of MR30365/07 and fentanyl on ventilation and analgesic responses to noxious electrical and heat stimulation in healthy volunteers, by performing pharmacokinetic / pharmacodynamics (PK/PD) modeling…