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A randomized, placebo and active comparator (oxycodone)-controlled study on the effect of tapentadol on respiration and analgesia in healthy volunteers

The objective of this study is to investigate the extent of respiratory depression at equi-analgesic dosages of tapentadol and oxycodone

Cannabis-opioid interaction in the treatment of fibromyalgia pain - an open label proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodon combination.;substudy: follow-up vragenlijst

The main objective is to assess whether Bediol (containing THC and CBD) co-treatment will reduce opioid side effects in chronic pain patients. A secondary objective will be that Bediol is superior to oxycodone in the relief of chronic fibromyalgia…

Respiratory effects of tapentadol and oxycodone assessed by pharmacokinetic-pharmacodynamic and response surface modeling in healthy volunteers

To construct the utility surfaces of tapentadol and oxycodone.