2712 results
The primary objective of the study is to determine the gain in effectiveness of TE compared with P when applied to remove excess iron during maintenance therapy of HH patients.
To study the effects of Mindfulness training in adults with ADHD on ADHD symptoms and comorbidity with affective and anxiety symptoms. Also, the feasibility of Mindfulness training will be evaluated in this specific patientgroup and the effect on…
Primary Objective: Improvement in myocardial blood flow and reverse remodelingSecondary Objective(s): Improvement in wall motion abnormalities, left ventricular function and NYHA class
Primary objective is to assess differences in endogenous hypoxia markers (CA9, PAI-1, VEGF [Rademakers et al. 2008]) and autophagy (LC3b [Rouschop et al. 2010]) before and after short-term pre-surgical treatment with HCQ in breast cancer patients.…
The aim of this study is to demonstrate which is the most effective operation for neonates with necrotizing enterocolitis (NEC): intestinal resection with stoma formation or intestinal resection with primary anastomosis.
The objective of this study is to evaluate the effect of C-mill training on step adjustments in stroke patients, in order to gain insight into the suggested working mechanisms. Before and after the C-mill training, the participants will be tested…
The main objective of this study is to show that the basilic vein transposition in the current elderly population is superior to the brachiocubiti fistula in terms of easy cannulation and maturation. Primary outcome is one year patency We will also…
Primary objectives of the study are to assess whether the administration of p53-SLP together with the local administration of IFNα is safe and able to induce a strong (directly ex-vivo detectable) p53-specific CD4+ T-cell response. Secondary…
Validation of the DBS sampling method of cyclosporin in TDM practice
Assess whether InsuVital intake improves the postprandial glucose, insulin and C-peptide response
Does ECT in combination with nortriptyline result in a more likely and or faster response than ECT alone? Does continuation pharmacotherapy with nortriptyline result in a lower relapse rate or longer time to relapse in responders to ECT in…
At time of publication
The aim of the research is to evaluate the efficacy and working mechanisms of the "active lifestyle" intervention, which is directed to strategies to prevent low levels of daily activities and poor fitness in adolescents and young adults…
The objective of this pivotal study is to assess the PK and PD as well as safety and tolerability of RP103 compared to Cystagon® in patients with nephropathic cystinosis. Results of this Phase 3 study will be used to support the registration…
Primary aim of this study is to assess changes in body composition in patients with a carcinoma in the larynx, pharynx or oral cavity, in the period during and after treatment.Secundary aims of this study are:- to assess predictive factors for…
We would like to test the system in a pilot study with vulonteers with mild depressive symptoms. The goals of this pilot are twofold:1) We want to know how easy to use the system is and how content the volunteers are with this form of treatment en…
To evaluate the feasibility of PENS in patients with chronic neuropathic pain due to SCI.
The study described in this protocol is designed to determine the pharmacokinetics of cefotaxime and its metabolite, desacetyl-cefotaxime, in children on continuous intravenous infusion of cefotaxime. Using these data we will be able to delineate…
To analyse possible differences in functional deficit and donor-site morbidity between the routinely used free osteocutaneous fibular flaps and the free fibula osteomyocutaneous (with flexor hallucis longus ) flap.
To define dosing regimens of morphine, haloperidol and midazolam based on specific patient characteristics, the so-called pharmaprofile. A population PK/PD model will be developed, followed by defining the relation between the pharmaprofile and PK/…