756 results
To investigate the HPA axis function and the glucocorticoid receptor function after high-dose glucocorticoid therapy during treatment for childhood ALL and lymphoma. With these results, a more robust approach on glucocorticoid coverage during…
In a randomized single-blinded trial we compare two treatments for GTS and CTD patients. The primary aim of this study is to compare the efficacy of the D2-blocking agent risperidone with ERP-therapy in tic reduction. Dropout rates and side effects…
The objective of this study is to evaluate the effects of resveratrol on apo A-I concentrations in subjects with low serum HDL-cholesterol (HDL-c) concentrations at baseline. Minor objectives are to study the effects of resveratrol in the same…
The objectives of this study are to evaluate the safety and efficacy of AGN-214868 compared with placebo in the treatment of patients with IOAB and urinary incontinence.The clinical hypotheses for this study are:• AGN-214868 has an acceptable safety…
The primary objective of this study is:To evaluate the efficacy of a regimen containing GS 9350-boosted Atazanavir versus ritonavir-boosted atazanavir each administered with emtricitabine/tenofovir disoproxil fumarate in HIV 1 infected,…
Primary: Antiviral efficacy of dolutagravir in combination with Kivexa (abacavir en lamivudine) after 48 weeks of treatment in comparison with Atripla (tenofovir, emtricitabine and efavirenz). Secondary: Antiviral efficacy after 96 and 144 weeks,…
To determine if maintenance treatment with lenalidomide prolongs progression free survival in patients with advanced stage CTCL that has notbeen previously treated with intravenous chemotherapy except the chemotherapy received in the preceeding…
To investigate whether preventive use of the antibiotic ceftriaxone improves functional health outcomes in patients with stroke by preventing infection. This will be done in a large multi-centre randomized controlled trial. Within this trial we will…
1. Primary objective:To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from OIC.2. Secondary objectives:To assess the safety and…
The objective of the current study is to investigate the efficacy, safety and tolerability of BI10773 (25mg once daily) compared to glimepriride (1-4mg daily) given for 104 weeks with a 104-week extention period in patients with type 2 diabetes…
To replicate and extend the findings of the recent methylphenidate study in which methylphenidate was found to enhance episodic memory performance; To explore whether this effect of methylphenidate is primarily mediated by its dopaminergic action.
A practical demonstration project in 5 European countries to show that intensive smoking intervention during a preventive cardiovascular risk management programme for patients with cardiovascular (CVD) or other atherosclerotic disease, asymptomatic…
1. To assess the effect of odanacatib 50 mg once weekly versus placebo on lumbar spine BMD over 24 months.2. To assess the safety and tolerability of odanacatib 50 mg once weekly compared to placebo.
To investigate the outcome after induced hypertension versus no induced hypertension in patients with DCI after aneurysmal SAH.
Primary Objective:To demonstrate that CHF 1535 twice daily is superior to Formoterol twice daily in terms of COPD exacerbations rate during 48 weeks of treatment and in terms of pulmonary function (change in pre-dose morning FEV1 from baseline to 12…
Primary objective:Are coping style and quality of life different in patients receiving PST from patients receiving standard care after the intervention, after 6 months and after 12 months? Secondary objectives:1. Are amount of health care…
The main objective of the study is to investigate the physiological effects of high intensity interval training (HIT) at the skeletal muscle level by assessing skeletal muscle re-oxygenation, skeletal muscle metabolic recovery and re-oxygenation…
The overall aim of the project is to improve health outcomes and autonomy of CKD patients by testing a self-management care model regarding hypertension control. Furthermore, this study will investigate the impeding and facilitating factors for…
The purpose of this study is to investigate the effectiveness of pelvic physical therapy as a SURPLUS to the paediatric usual care in children (5-17 years) with functional constipation.Other research questions are: Does pelvic physiotherapy…
Primary: To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in male subjects with chronic constipation.Secondary: To evaluate the safety, tolerability, effect on quality of life and effect on symptoms of prucalopride…