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The metabolic response during low-frequent and high-frequent neuromuscular electrical stimulation of the quadriceps muscles in patients with chronic obstructive pulmonary disease

Comparing the metabolic response (oxygenuptake and ventilation) and symptom perception (borgscores for dyspnoea and fatigue) between neuromuscular electrical stimulation with low-frequency and high-frequency.

A four-arm randomised, double-blind, placebo-controlled, multicentre Phase II study to evaluate the safety, tolerability and efficacy as assessed by frequent MRI measures of three doses of atacicept monotherapy in subjects with relapsing multiple sclerosis (RMS) over a 36 weeks treatment course.

Primary Objective: • The primary objective of the study is to evaluate the efficacy of three doses of atacicept to reduce CNS inflammation in subjects with RMS as assessed by frequent MRI.Secondary Objectives: • Evaluate safety and tolerability of…

Select Stim: Selective stimulation of the subthalamic nucleus in Parkinson*s disease
"A feasability study"

The primary objective is to avoid cognitive and affective side effects and maintain the beneficial motor effects by selective stimulation of the STN motor part. With the Select Stim project we want to improve the classical operation procedure, in…

Value of PET-CT in Radiation Treatment Planning for Patients with Esophageal Cancer (RESPECT-shadow-study)

The present study is intended to prospectively evaluate the validity of PET/CT with regard to target volume definition by assessing the incidence of locoregional recurrences outside the CTV among patients with esophageal cancer.The hypothesis to be…

Genital and subjective sexual response in women after close rectal restorative proctocolectomy with ileal pouch anal anastomosis: a comparative clinical study

To assess whether close rectal restorative proctocolectomy with IPAA has a better outcome regarding postoperative vaginal vasocongestion and reported psychological and sexual functioning then IPAA by TME restorative proctocolectomy.

A multi-center, single-dose, open-label, randomized, parallel group study to investigate the reduction of initial taspoglutide Cmax after administration of 20 mg taspoglutide 10% Sustained Release Formulation (SRF) using three modified formulations as compared to the current Phase 3 formulation in healthy volunteers.

Primary:to assess the reduction of initial study drug Cmax after administration of 20 mg study drug 10% SRF using three modified formulations as compared to the current Phase 3 formulation in healthy volunteers.Secondary:to assess the safety and…

Web-based insulin titration: Improving diabetes care in the Netherlands. A pilot study of the PANDIT® system.

The main purpose of this pilot study is to evaluate the safety of the PANDIT system by testing the system in a group of patients, under strict supervision of a diabetes nurse. The main objective is to check whether PANDIT provides correct insulin…

Remotely controlled, small intestinal release of 99mTcpertechnetate using an ingestible electronic device: the IntelliCap

The goal of the current study is to investigate the correlation of IntelliCap generated environmental information (gastrointestinal pH and temperature) with an established nuclear imaging technique. In addition, the functionality of the IntelliCap…

Peripheral targeting of inhaled rhDNase for chronic obstructive asthma in childhood.

Primary Objective: To investigate the effect of treatment with nebulized rhDNase on pulmonary function in children with asthma and persistent obstructive pulmonary function.Secondary Objectives: To investigate the effect of treatment with nebulized…

Hypnotherapy for adolescents and adults with inflammatory bowel disease and symptoms compatible with irritable bowel syndrome

To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.

CINCOR* Trial

The purpose of this clinical study is to provide confirmation of the clinical safety and performance of the CINCOR* System in patients at risk of developing CIN who are undergoing interventional percutaneous coronary procedures.Further, the data…

MULTICENTER STUDY WITH A 16-WEEK DOUBLE-BLIND, PLACEBO-CONTROLLED (DURING THE INITIAL 2 WEEKS) RANDOMIZED PERIOD, FOLLOWED BY A 24-WEEK OPEN LABEL EXTENSION TO ASSESS MAGNETIC RESONANCE IMAGE-VERIFIED EARLY RESPONSE TO CERTOLIZUMAB PEGOL IN SUBJECTS WITH ACTIVE RHEUMATOID ARTHRITIS

The purpose of this study is to identify the first time-point the OMERACT RAMRIS score for the activity of synovitis is statistically significantly reduced compared to Baseline, in response to cerolizumab pegol (CZP) therapy. In addition, the early…

Renal hemodynamic effects of aliskiren (rasilez) in comparison to ramipril (tritrace) in patients with overweight/obesity and hypertension

The primary objective of this study is to determine the effects of aliskiren, as compared to ramipril, on renal hemodynamics in overweight/obese and hypertensive patients.

Effect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling

Right ventricular function will be assessed by invasive pressure-volume loop analysis using combined pressure-conductance catheters [27,28]. The response of right ventricular function to increased afterload, induced by brief, partial clamping of the…

Autophagy inhibition using hydrochloroquine in breast cancer patients: a pilot study

Primary objective is to assess differences in endogenous hypoxia markers (CA9, PAI-1, VEGF [Rademakers et al. 2008]) and autophagy (LC3b [Rouschop et al. 2010]) before and after short-term pre-surgical treatment with HCQ in breast cancer patients.…

THE PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION BETWEEN PROPOFOL AND KETAMINE WHEN GIVEN FOR SEDATION AFTER CARDIAC SURGERY
IN THE INTENSIVE CARE UNIT.

1. To quantify the influence of propofol on the distribution, redistribution and elimination of ketamine and to evaluate the importance of hemodynamic parameters on the pharmacokinetics of ketamine.2. To quantify the influence of ketamine on the…

Audiometric evaluation of tinnitus inhibition by cochlear implant stimulation.

To evaluate the efficacy of various masking strategies in cochlear implants as a treatment for tinnitus in patients with profound hearing loss.

The Neurobiological Basis of Disengagement:
A Mechanism Implicated in Visuospatial Attention.

Our primary objective is to provide a model which accounts for the inconsistencies in the pharmacological literature regarding the role of the noradrenergic and cholinergic system in visuo-spatial attention. Recently we started a University Medical…

STAT Trial: Stoma or Intestinal Anastomosis for Necrotizing Enterocolitis of the Neonate: Multicentre Randomized Controlled Trial

The aim of this study is to demonstrate which is the most effective operation for neonates with necrotizing enterocolitis (NEC): intestinal resection with stoma formation or intestinal resection with primary anastomosis.

Feasibility of technology-assisted task-oriented skill training of the upper extremity in persons with a cervical spinal cord injury: a pilot study

The aim of this project is to assess the feasibility of the technology assisted training to improve arm hand skilled performance using the Haptic Master in persons with C-SCI.Research questions:Is it feasible to train persons with a C-SCI with a…