721 results
Primary:• To evaluate the efficacy of PTC923 in reducing blood phenylalanine (Phe) levels in subjects with phenylketonuria (PKU) as measured by mean change in blood Phe levels from baseline to Weeks 5 and 6 (ie, the average of each respective…
Primary objective: to study in patients with heart failure and AF whether PVI or atrioventricular node ablation is non inferior with regard to all-cause mortality, cardiovascular hospitalization or changes in quality of life. Secondary objective: to…
This study has been transitioned to CTIS with ID 2024-514461-19-00 check the CTIS register for the current data. Phase 1 - Primary Objective• To determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of single-agent MCLA-…
Objectives of Part A, B and C are the following: Part A: determination of the optimal mass dose of S095012 to inject with 89Zr-S095012 and optimal time point for PET scans for appropriate visualisation of 89Zr-S095012 through PET imaging. Part B…
The primary objective is to compare the IntelLeg Knee on the execution of a subset of daily activities for individuals with a transfemoral amputation to auto-adaptive or mechanical (non-powered) prosthetic knee via musculoskeletal simulation. The…
We aim to fill the gap between the 50% of patients helped by standard therapies (ERP with/without SSRIs) and the 1% receiving surgery by using a non-invasive alternative: repetitive transcranial magnetic stimulation (rTMS) to potentiate the effects…
Primary objective:To establish and propagate a bladder cancer / immune cell co-culture model to study patient response to immunotherapy ex vivo. (Can organoid and immune cell co-cultures be maintained for 3 passages?) Protocols will be improved…
To evaluate the safety of EndoArt® in subjects with chronic corneal edema.
Primary Objective: To evaluate the safety of high-dose rifampicin (35 mg/kg/d) supplemented with standard doses of isoniazid, pyrazinamide, and ethambutol for 8 weeks in adult subjects with pulmonary or extrapulmonary DS-TB belonging to difficult to…
The aim of this pilot study is to evaluate the feasibility of an online platform that targets depressive symptoms in an elderly population (55+) by means of an online treatment platform (Moodbuster) for depression in a pretest-posttest design.
The primary objective of this study is to examine whether MIS is non-inferior to laparotomy in terms of disease free survival (DFS) in women with advanced stage EOC that received 3 to 4 cycles of NACT.
The purpose of this study is to determine the effect of using the Happi Liver application on the course of the liver disease non-alcoholic fatty liver disease (NAFLD).
The main objectives of this study are:1. The effect of high (2L) vs low (1L) volume bowel preparation on the quality of life of patients undergoing colonoscopy. 2. The cost-effectiveness of low-volume bowel preparation versus high-volume preparation…
- Confirming the survivorship under normal use of the Collared and Collarless versions of the Avenir Complete* stem (Standard, High Offset, Coxa Vara) and its instrumentation used in primary total, hemi, or revision hip arthroplasty by recording the…
The aim is to evaluate whether the use of eRFA prior to stenting prolongs stent patency in patients with biliary obstruction due to inoperable perihilar cholangocarcinoma.
Main objective:To improve the functional neurological outcome of patients, as measured on the Raschbuilt Overall Disability Scale (RODS) for inflammatory neuropathies (iRODS) with Zanubrutinib in combination with standard treatment with Rituximab or…
Clinical safety study on 5-Aminolevulinic acid (5-ALA) in children and adolescents with brain tumors
This study has been transitioned to CTIS with ID 2024-517575-20-00 check the CTIS register for the current data. This study proposes a safety study in children in which tumors are operated on using fluorescence-guided resection which are similar to…
This study has been transitioned to CTIS with ID 2024-515278-28-00 check the CTIS register for the current data. To analyze the molecular effects and dose-response relationship of HBOT in patients with moderate-to-severe UC refractory to medical…
To evaluate the effects of a bariatric surgery strategy on clinical endpoints, cardiac parameters and functional status in patients with obesity (with BMI 32-40 kg/m2) and symptomatic HF with preserved or mildly reduced LVEF in combination with AF.
Safety Run-in (SRI) part:To confirm the recommended phase 2 dose (RP2D) of NIS793 or any other investigational drug(s), in combination with SOC anti-cancer therapy. In protocol amendment 1, an arm with tislelizumab has been added. In this arm, the…