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A prospective, double-blind, placebo-controlled trial investigating the efficacy and safety of Org 25935 in relapse prevention in subjects with alcohol dependence

Primary objective- To assess the effects of Org 25935 on heavy drinking in subjects with alcohol dependence.Secondary objectives- assess the effects of Org 25935 on the amount of drinking- To assess the effects of Org 25935 on the first relapse to…

DCE MRI in the follow-up of prostate cancer patients after radiotherapy; a matched case control stuy (Pilot)

To measure the differences of DCE MR images between patients with and without local recurrent prostate cancer in the follow up after primary treatment.

A Randomized, Open-Label, Multinational Phase 3 Trial Comparing Amrubicin Versus Topotecan in Patients With Extensive or Limited and Sensitive or Refractory Small Cell Lung Cancer After Failure of First-Line Chemotherapy

The primary objective is to demonstrate superiority in overall survival of amrubicin (40 mg/m2 administered as a 5-minute infusion once daily for 3 consecutive days starting on Day 1 of a 21-day course) compared with topotecan hydrochloride (…

Pilot Study: are human intestinal biopsies usefull as in vitro model for the small intestine

Human intestinal biopsies will be used to further develop an in vitro intestinal model. This model will the be used for future research to study the effect of nutreints and drugs on intestinal function. The human biopsies will be compared with…

Open-label, non-randomized, positron emission tomography (PET) imaging study to evaluate a single dose of 250 MBq (6.75 mCi) ZK 6032924 (18F-FEDAA1106) for its diagnostic potential in discriminating patients with probable Alzheimerâ¤*s disease from healthy volunteers and to evaluate the radiation dosimetry of a single dose of 185 MBq (5 mCi) ZK 6032924 in healthy volunteers.

Discrimination of probable AD patients from healthy volunteers by ZK 6032924 PET imaging as evaluated by visual analysis of the brain distribution patterns and by SUV values in probable AD patients as compared to healthy volunteers for brain imaging…

Erythrocytapheresis versus Phlebotomy as maintenance therapy in patients with hereditairy hemochromatosis; a randomised, single blinded, sequential, cross-over trial

The primary objective of the study is to determine the gain in effectiveness of TE compared with P when applied to remove excess iron during maintenance therapy of HH patients.

The effectiveness of antidepressants and psychological interventions in treating conversion disorder, motor type: a randomized placebo controlled clinical trial.

To examnine the effectiveness of psychological interventions and psychopharmacological interventions compared to placebo-control.

In vivo human carotid artery atherosclerotic plaque characterization with high-resolution MRI at 3 and 7T

Primary goal:To investigate whether specific plaque characteristics are associated with ischemic lesions, especially (clinically silent) cerebral micro-infarcts, we will perform preoperative high resolution 3 and 7 Tesla MR plaque imaging in…

A Phase 1/2, Ascending Multiple-Dose Study to Evaluate the Safety, Efficacy and Pharmacokinetics of BMS-753493 in Subject with Advanced Cancer

To determine the maximum tolerated dose, dose limiting toxicity and recommended Phase 2 dose of BMS-753493 in subjects with advanced cancer.

A new diagnostic development in MRI screening for breast cancer

Primary objective:To compare the specificity of multiple voxel MR spectroscopy with MRI.Secondary objective: To decrease the number of false positive diagnostic outcomes by using multiple-voxel MR-spectroscopy and therefore to reduce benign biopsies…

Assessment of tumor hypoxia in laryngeal cancer with 18F-fluoroazomycin arabinoside (18F-FAZA)-PET/CT scanning, oxygen-enhanced MRI (OE-MRI) and immunohistochemistry

To determine the accuracy of 18F-FAZA-PET/CT and OE-MRI scan in detecting hypoxic regions within the tumor using histological markers.

The effect of a mixture of probiotics on constipation symptoms in pregnant women

Hypotheses1) The use of a combination of probiotic strains results in a significant increase in defecation frequency in pregnant women with constipation.2) The use of a combination of probiotic strains results in less episodes of difficult…

Randomised evaluation of surgery with craniectomie for uncontrollable elevation of intra-cranial pressure

The aim of this trial is to determine the effectiveness of an operation (decompressive craniectomy), compared to medical management alone, to treat brain swelling and improve outcome. The results of this trial will better define the indications for…

Mindfulness training in adults with Attention Deficit Hyperactivity Disorder*A randomised, controlled study.

To study the effects of Mindfulness training in adults with ADHD on ADHD symptoms and comorbidity with affective and anxiety symptoms. Also, the feasibility of Mindfulness training will be evaluated in this specific patientgroup and the effect on…

Spatio-Temporal Image Correlation; the Key to fetal EchocaRdiography
Part III signs of decompensation in growth-restricted fetuses

The focus of this study is to get more insight in the pathophysiology of IUGR. The main goal is to investigate the applicability of STIC in determining fetal cardiac function in IUGR.

A Phase I Study to Evaluate the Safety and Tolerability of the Histone Deacetylase Inhibitor, CHR-2845, in Patients with Advanced or Treatment Refractory Haematological Diseases or Lymphoid Malignancies

Primary objective:* To determine the safety, tolerability, dose-limiting toxicities (DLT), maximum acceptable dose (MAD) and maximum tolerated dose (MTD) of CHR-2845 when administered orally to patients with advanced or treatment refractory…

A Phase III, randomised, parallel group, double-blind, double-dummy, active comparator -controlled, multi-center study to assess the efficacy and safety of PGL4001 (ulipristal) versus GnRH-agonist (leuprorelin 3.75mg) for pre-operative treatment of symptomatic uterine myomas.

Efficacy Objectives:- Primary objective of this study is to demonstrate non inferior efficacy of PGL4001 versus GnRH-agonist to reduce, prior to surgery, excessive uterine bleeding caused by uterine myomas.- Secondary objectives are to demonstrate…

A Five-Tier, Phase 2 Open-Label Study of IMC-A12 Administered
as a Single Agent Every 2 Weeks in Patients With Previously-
Treated, Advanced or Metastatic Soft Tissue and Ewing's
Sarcoma/PNET

The primary objective of this study is to determine the progression-free survival (PFS) rate assessed 12 weeks after the initiation of IMC-A12 monotherapy, administered every 2 weeks to patients with previously-treated, advanced or metastatic soft…

A multi-center, parallel-group, comparative trial evaluating the efficacy, pharmacokinetics and safety of 4.0 mg.kg-1 sugammadex administered at 1-2 PTC in subjects with normal or severely impaired renal function

Objective is to show equivalence with respect to the efficacy of sugammadex in subjects with normal or severely impaired renal function, to evaluate the safety of sugammadex in these subject groups and to compare the pharmacokinetic profiles.

An Open-Label Study to Investigate the Pharmacokinetics (Distribution, Metabolism, and Excretion) of Bendamustine Hydrochloride Following Intravenous Infusion of [14C]Bendamustine Hydrochloride in Patients With Relapsed or Refractory Malignancy (Hematologic or Nonhematologic)

The primary objective of the study is to quantitatively determine the pharmacokinetics (distribution, metabolism, and excretion) of [14C]bendamustine and its metabolites in patients with confirmed, relapsed or refractory malignancy (hematologic or…