1039 results
To evaluate the effectiveness of eccentric calf muscle exercise therapy compared to strength training of the upper extremities (control group) in patients with chronic midportion Achilles tendinopathy.
Both interventions (GRAIL training & endurance and strength training (control intervention)) will result in an increase in gait speed, functional walking ability and social participation. However, the GRAIL training will result in larger…
Benign liver tumors and cysts carry a significant burden on the quality of life in some cases. Apart from impairing symptoms, psychological burden might provide sufficient ground for surgical intervention. There is a variable approach to them…
Point of care testing with Fcal POCT will reduce substantial the referral rate of children with chronic GI symptoms to the paediatrician.
This multicentre randomised controlled trial aims to investigate whether PoCUS can be used as an adjunct to improve first attempt success rate in closed reductions of displaced distal radial fractures in adults in the ED.
The rationale of this study was to investigate the alteration of colonic motor patterns in the early postoperative stage and between patients with no or minor LARS-symptoms (LARS-score < 30) compared to patients experiencing major LARS…
The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…
This study aims to gain clarity on the issue of treatment for clinical levels of social anxiety in adolescents by testing the effectiveness of a group-based intervention. Most importantly, it aims to research the effectiveness of an added mHealth…
Primary objective To evaluate the Overall Response Rate (CR/PRrate) in patients treated with pembrolizumab for recurrent or progressive PCNSL after MTX-based first-line therapy To evaluate the safety of pembrolizumab in subjects diagnosed with…
To investigate if patient controlled sublingual sufentanil tablets as compared to patient controlled intravenous morphine lead to improved independent mobilization on postoperative day 1 after laparoscopic donor nephrectomy (LDN).
Primary Objective: Non- invasive determination of the oxygenation values and the haemoglobin concentration of retinal arteries and veins by means of retinal imaging.
There is evidence however that abdominal wall blocks, such as TAP blocks, could help managing the postoperative pain, but covering the visceral pain is not possible with this technique. It is not even clear to date which component of pain, the…
This study investigates the impact of a goal directed nutritional support protocol on sarcopenia in oncological patients undergoing an esophagectomy and secondary the incidence of anastomotic leakage and pneumonia, surgical infection and lenght of…
Safety:* Evaluate the safety of AVXS-101 through incidence of adverse events (AEs) and/or serious adverse events (SAEs)* Evaluate the safety of AVXS-101 based on the change from baseline in clinical laboratory parametersEfficacy objectives will be…
Primary objectiveTo evaluate if tralokinumab after 14 weeks of treatment (at steady state) changes the metabolism of substrates of CYP 1A2, 2C9, 2C19, 2D6, or 3A4 pathways in subjects with moderate-tosevere atopic dermatitisSecondary objectivesTo…
Investigating the progress of the self-esteem and well-being before, during and after the Dramatherapeutic Self-Image module in clients with a personality disorder who are in treament phase 1 of outpatient schema focused therapy.Investigating which…
Primary: to determine if inhibition with GPB can provide a significant (>30%) reduction in the accumulation of orally administered Iodine-123 in salivary glands, measured at 4h after administraion. Secondary: to determine if a reduction at 4h…
Primary Objective:The main objective of this study is to investigate the effectiveness of BEAR (a parent training combining e-learning and home visits) compared to care-as-usual (CAU) in young children (12-30 months) who are at risk of developing…
2.1 HypothesisPrimary infection with Mtb induces temporal changes in the innate immune system, known trained innate (aangeboren) immunity, and the extent of trained innate immunity influences subsequent activation of adaptive (verworven) immunity.2.…
This is an exploratory validation study in a small group of subjects receiving a CI to verify if ECoG measurements with AB*s novel ECoG system are useful as an intra-operative tool for soft surgical techniques to spare residual hearing. This trial…