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Investigation of DNA medication passport for antidepressants in primary care.

Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.

Effectiveness of EMDR for adolescents with Major Depressive Disorder

the application of EMDR therapy is associated with a significant decrease in severity of depressive symptoms and decrease of percentage of patients meeting DSM-5 criteria for MDD compared to the waiting list. Participants receiving EMDR report after…

Magnetic non-Invasive acupuncture for Infant comfort during retinopathy of prematurity examination

To investigate whether non-invasive ear magnetic acupuncture will help reduce pain and stress for preterm infants in the Neonatal Intensive Care Unit (NICU) during their routine eye examination for Retinopathy of Prematurity (ROP).

High Loading Dose of Paracetamol in the Emergency Department

To investigate if a high loading dose of 2 grams paracetamol has a beneficial effect on pain sensation or has an opioid-sparing effect in patients with pain in the Emergency Department

Comparing cooling and non cooling of burs during placement of dental implants.

Primary objective: The primary goal of this research is to compare peri-implant hard tissue around implants placed using a modified drilling protocol, i.e. a reduced drilling speed without cooling and around implants inserted using a default…

Heart rate registration in neonates using a PPG-integrated cap

Primary Objective: To assess the agreement between the heart rate assessed with a dedicated cap with integrated PPG-leads and standard ECG monitoring using regular neonatal thoracic electrodes as reference technique.Secondary objectives:Does…

LEFTSTYLE advice for nocturnal reflux symptoms

The main objective of the study is to investigate if sleep positional therapy, using the LEFT, reduces nighttime gastroesophageal reflux symptoms.

Modified Exclusive Enteral Nutrition with the Crohn's Disease Exclusion Diet for Induction and Maintenance of Remission and Re-biosis

To prove that sustained clinical remission can be maintained at week 14 with a new dietary strategy that involves only 2 weeks of EEN with Modulen and 22 weeks of an exclusion diet involving selected table foods. We hypothesize that use of EEN for…

Bilateral prophylactic mastectomy; Should we preserve the pectoral fascia?

To assess a pilot-study on the impact of removal versus preservation of the pectoral fascia on total drain volume, time to drain removal and needle aspirations (and thus seroma) in women undergoing bilateral prophylactic mastectomy.

Preventing Relapse After Successful Electroconvulsive therapy (ECT) for Depression: A randomized controlled trial on lithium as add-on to personalized maintenance ECT

Although electroconvulsive therapy (ECT) is an effective treatment for depression, preventing relapse after successful ECT remains a major challenge. In the PRASED-study we evaluate the effectiveness of three strategies to reduce relapse: an…

Sulodexide for chronic heart failure: a proof of concept, randomized, open-label, placebo-controlled study

To assess the efficacy of treatment with sulodexide for chronic heart failure.

*Tackle your Tics: effectiveness of a brief, intensive group-based exposure therapy programme for children with tic disorders: a randomized controlled trial*

The aim is to study the effectivity of a brief, intensive, outpatient group treatment (ERP) for youths with chronic tic disorders/Tourette Syndrome (TS), to improve treatment outcome, daily functioning/quality of life and treatment satisfaction. If…

First in Human Study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of PPSGG (PN-1007) in anti-MAG neuropathy patients.

Primary objectiveTo assess the safety and tolerability after single and multiple intravenous administrations of PPSGG in patients suffering from anti-MAG neuropathy.Secondary objectives- To evaluate the PK of PPSGG after single and multiple…

How effective is local treatment of Molluscum Contagiosum compared to whatchful waiting?

The aim of this study is to compare the effect of early treatment on healing and quality of life with the usual expectant policy in children with mollusca contagiosa.

Feasibility and preliminary effectiveness of a preoperative training and nutrition intervention in people with sarcopenic obesity who receive total hip or knee arthroplasty within the 'Actief Herstel' care pathway

The objective of this study is to evaluate the feasibility and to determine the preliminary effects on physical functioning, muscle function, body composition and postoperative recovery of a combined preoperative nutrition and exercise intervention…

Blink reflex changes after GON-injection in cluster headache: Clinical and pathophysiological implications.

To investigate if the GON-injection affects trigeminal threshold and transmission using the R2 component of the blink reflex.

The treatment of venous thromboembolism with edoxaban in patients with cirrhosis, a pharmacokinetic study.

To assess the safety and effect of edoxaban in Chil-Pugh B cirrhosis.

A phase II, open label study to investigate the efficacy and safety of domatinostat in combination with avelumab in patients with advanced unresectable/metastatic Merkel Cell Carcinoma progressing on anti-PD(L)1 antibody therapy - the MERKLIN 2 study

Objectives:Primary Objective: to investigate the anti-tumor efficacy of domatinostat in combination with avelumab in advanced unresectable/metastatic MCC patients progressing on anti-PD-(L)1 antibody monotherapy.Secondary Objectives: to investigate…

A Phase 3 Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Rozanolixizumab in Adult Study Participants With Persistent or Chronic Primary Immune Thrombocytopenia (ITP)

Primary:* To demonstrate the clinical efficacy of rozanolixizumab in maintenance treatment in study participants with primary ITPSecondary:* To assess the safety and tolerability of rozanolixizumabExploratory:* To evaluate the clinical efficacy as…

A randomized, double-blind, placebo-controlled, multiple ascending dose study to examine the safety, tolerability and pharmacokinetics of orally administered PHA-022121 in healthy subjects.

Primary ObjectiveTo assess the tolerability and safety of multiple ascending oral doses of PHA-022121 administered after a standard caloric meal in healthy adult subjects.To assess the PK characteristics of PHA-022121 after administration of…