247 results
Primary Endpoint: Feasibility of including patients in the study, randomization and delivery of the intervention. To assess the primary endpoint, we will examine the probability that: (1) a screened patient is eligible; (2) an eligible patient…
The primary objective of this study is to determine the safety and feasibility of turbine-based insufflation, measured in terms of occurrence of adverse device effects and serious adverse device effects. The secondary objectives are to determine the…
To determine whether guided growth of the proximal femur decreases the risk of further hip migration and need for further surgery in cerebral palsy patients.
The main objective is to investigate whether the additional use of IVUS leads to an increase in net lumen gain (NLG) when compared with standard angiography-guided endovascular treatment as measured during control IVUS after six weeks. Secondary…
To evaluate the effect of transcutaneous electrical nerve stimulation (TENS) in patients with ANOCA on the change in the summary score of the Seattle Angina Questionnaire (SS SAQ) after 1 month treatment with TENS, compared to baseline.
To test whether tACS in a theta frequency enhances extinction of physiological stress responses to exposure to anxiety- or trauma-related stimuli or memories. Secondarily, to examine the influence of baseline neuroendocrinological response, baseline…
To investigate the fluctuation patterns of different pulmonary parameters in patients with severe asthma, before and after starting a treatment with biologics, using daily measurements with the Respicorder device.
This study aims to evaluate the Corsano Cardiowatch 287-2 for heart rate, heart rate variability (RR intervals), oxygen saturation, respiratory rate, and blood pressure during strenuous activities such as High-Intensity Interval Training (HIIT).…
Demonstrate that the self-expandable Allegra TAVI system provides lower mean gradient assessed by TTE compared to balloon-expandable valve systems in a population of all women patients with symptomatic severe aortic valve stenosis.
The objective of this study is to evaluate the safety and effectiveness of the PerQseal Elite vascular closure system when used to achieve haemostasis of common femoral venotomies created by 14 to 22F sheaths (venotomy up to 26F) in patients…
This study will initially focus on gaining insight into the difference between the current set PEEP level following cardiothoracic surgery compared to individually adjusting the PEEP level using EIT or Pes.
The primary goal of this study is to evaluate the effectiveness of VR-exposure therapy (VRET) in diminishing anxiety and avoidance within adolescents with social anxiety. We expect that, compared to the within-person baseline and standard treatment…
Primary Objective: Is the intervention model feasible and acceptable for clients, parents/caregivers, peers and therapists?Secondary Objective(s): 1) Establishing first evidence of efficacy of peer-mentored CBT in reducing anxiety in adolescents…
To answer the following questions; (1) What is the estimated effect size of personalized rehabilitation therapy for improving daily functioning in severely fatigued myositis patients, compared to usual care? (2) What are the societal costs of…
In the current study, the subjective and objective effectiveness of cognitive rehabilitation therapy for people with somatic symptom and related disorders will be investigated. Additionally, the effects of this treatment on brain activity in the…
To further evaluate the safety, efficacy and device performance of the ACURATE neo2* aortic bioprosthesis and ACURATE neo2* transfemoral delivery system in 2000 consecutive patients with severe aortic stenosis according to VARC-3 criteria.
The primary objective of the LION RCT is to assess the (cost-)effectiveness of a personalized, live-remote exercise intervention for cancer survivors on Health-Related Quality of Life (HRQOL) and the participants* main, self-reported side-effect.…
The objective of this study is to collect data on treatment outcomes when treating mCRPC using Lu-PSMA. In addition to this, the study aims to identify correlations between biomarkers (ctDNA and CTC*s) and dosimetry data with treatment outcomes of…
To improve survival and qualitity of life in patients with LAPC using ablative treatment with MRgRT (5x10Gy) in addition to standard of care.
The primary aim of this pilot study is to determine the acceptability of the intervention. The secondary aim is to elucidate factors that may facilitate or hinder the feasibility of the follow-up RCT (e.g., recruitment process) and to estimate the…