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ARP versus SH

To assess and compare ARP to spontaneous healing in damaged sockets (>50% buccal bone loss) in the posterior mandible regarding the additional need for bone augmentation either prior to or during implant placement 4-6 months after tooth…

Generation of induced Pluripotent Stem Cells from patients with severely complicated insulin-deficient diabetes

The objective of the study is to generate induced pluripotent stem cell lines from participants' blood in a GMP-compliant manner. These stem cells will be tested to confirm their pluripotency (having the ability to differentiate into any human…

Abscess drainage in Hidradenitis Suppurativa: Incision and Drainage versus Punch Debridement

This randomized-control trial is designed to determine the recurrence rate of HS abscesses following drainage via two methods: I&D with a linear incision and PD with an 8mm punch biopsy. In this context, recurrence is a newly described HS…

Open-label, fixed-sequence 3-period crossover study to determine the effects of repeated oral dosing of AQX-1125 on the pharmacokinetics, safety and tolerability of a combination oral contraceptive in healthy female subjects

The purpose of this study is to investigate how the uptake and elimination from the body (this is called pharmacokinetics) of a combination oral contraceptive (COC; 100 µg levonorgestrel and 20 µg ethinyl estradiol) is affected by the…

Pilot study: FES-assisted gait training intervention to improve gait in individuals with an incomplete spinal cord injury

1) To investigate whether an FES-assisted gait training intervention with FES (the Teslasuit) is feasible.2) To investigate whether an FES-assisted gait training intervention with FES (the Teslasuit) is safe.3) To investigate whether an FES-assisted…

Isolation of T cell receptors from human papilloma virus (HPV)-reactive or other tumor-reactive T cells from patients with oropharyngeal, cervical or vulvar cancer

The primary objective of this study is the isolation of TCRs from HPV-reactive or other tumor-reactive T-cells that were present in the tumor and/or the blood of patients with cervix, vulva, or oropharyngeal cancer. The secondary objective is to…

Evaluating re-innervation of the skin dermal fibers after avulsion

Evaluate the re-innervation of the skin neural fibres in patients having received an avulsion surgical approach to treat their extensive burn wound. This evaluation will be executed using both subjective (i.e. questionnaires) measures and objective…

Muscle morphology and hip muscle strength following a transfemoral amputation.

The primary objective of this study is to investigate the muscle morphology and muscle function of the residual limb compared to the intact limb in individuals with a TFA, and to explore their interrelationships. The secondary objectives are to…

Comparison of *lesion by lesion* and field photodynamic therapy in the prevention of actinic keratoses: a randomised, split face, single blind pilot study

To compare the efficacy of lesion to lesion treatment with field treatment with photodynamic therapy in actinic keratoses of the face or scalp Primary Objective: • Relapse rate of AK and incidence of new lesions at 9 months after PDT treatment •…

Long-term results of the arthroscopic Bankart procedure

Primary objectiveTo determine the incidence of recurrent instability (objectively measured using the Apprehension test, *Relocation test* and the *Release Test*) in our cohort of patients who underwent a Bankart procedure between January 1999 and…

A New Intervention for Implementation of Pharmacogenetics in Psychiatry.

PSY-PGx is the first initiative to propose a large-scale non-industry sponsored clinical study that aims to demonstrate the clinical benefits and potential of the implementation of pharmacogenetics for psychiatric patients in existing medical…

Paediatric Early versus late PArenteral Nutrition In Critical illness

The ultimate aim of this project is to answer the question whether insufficient EN should or should not be supplemented with PN early in the disease course of critical illness in children. Current medical practice and expert panels advocate the…

A multi-center, double-blind, randomized, placebo-controlled, cross-over study to evaluate the efficacy, safety and tolerability of SAF312 in subjects with neurogenic detrusor overactivity due to spinal cord lesions who are inadequately managed by antimuscarinic therapy (CSAF312A2202)

Primary: effects of SAF312 on the Maximum Cystometric Capacity (changes from baseline) versus placebo following one-week treatment.Secondary: Evaluation of the safety, tolerability and PK, PK/PD, additional parameters examined during cystometry,…

Acceptance and commitment therapy as an intervention to improve quality of life and activity-engagement in patients with multiple sclerosis.

The purpose of the current study is therefore to investigate the effectiveness of an ACT group intervention on both activity engagement and QoL in MS patients in comparison with a waiting list condition. Furthermore, we hypothesize that…

Platelet inhibition versus direct oral anticoagulation in patients undergoing percutaneous closure of patent foramen ovale or atrial septal defect

This study has been transitioned to CTIS with ID 2024-517115-70-00 check the CTIS register for the current data. Primary Objective: The goal of the study is to evaluate hemostasis, such as coagulation activation/thrombin generation and platelet…

Randomised Controlled Trial into the Effectiveness of Running Therapy in adult patients on Depression (EFFORT-D)

The objective is to assess the effectiveness of exercise therapy (running therapy or Nordic walking) ondepression in adults, in addition to usual care (primary aim) and on metabolic syndrome measures, qualityof life and cost effectiveness (secondary…

Inspire: INSpiratory muscle training for Patients admitted to ICU and outcomes on Recovery: a pilot randomized controlled trial

This pilot study aims to assess the feasibility of procedures for a future randomised multicentre trial (RCT) on IMT effectiveness after weaning from MV and to gather patient and physiotherapist experiences with IMT.