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BradycArdia paCemaKer with AV interval modulation for Blood prEssure treAtmenT (BACKBEAT Trial)

The primary objective of the study is to determine whether AVIM therapy in combination with medical therapy is more effective at reducing ambulatory systolic blood pressure (aSBP) and to determine whether AVIM therapy is safe.

Testing a tailored Home Exercise program to Gain insight into performance fatigability and
Reduce pain and fatigue In Patients with FSHD: THE GRIP on FSHD study

Primary objectives1. To determine the effect of a tailored exercise program by using the widely implemented exercise app *Physitrack* on experienced pain and fatigue in patients with FSHD.2. To investigate the relationship between perceived pain and…

Restorative Deepfake Intervention Netherlands (REDEFINE):
Deepfake survivor-perpetrator confrontation for young adults with sexual violence-related PTSD

To evaluate the acceptability and effectiveness of a deepfake victim-perpetrator confrontation in young adults with sexual violence-related PTSD.

*Combination of chemotherapy and adaptive Mr-guidEd Radiotherapy to improve outcomes in patients with esophaGEal adenocarcinoma (MERGE): a phase 1 dose finding trial*

The main objective of this study is to determine the maximum tolerated dose (MTD) of 5 fractions MRgRT for patients with AC following FLOT therapy. The secondary objectives are feasibility, non-dose limiting toxicity, oncological outcomes and to…

NEW characterizing rate of progression in USHer syndrome (NEW-USH) study
a natural history study in patients with Usher syndrome

The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.

Microbiome Intervention in Late-stage metastatic Lung cancer patients to improve response rate to immunotherapy

Investigate the effect of FMT from healthy obese donors on objective response rate (ORR according to RECIST criteria) in patients with metastasized or locally advanced NSCLC receiving standard of care first-line immunotherapy with or without…

Implantation of a non-diffractive extended depth-of-focus IOL and a monofocal IOL after myopic corneal laser refractive surgery: a randomized controlled trial.

The primary objective of this study is to compare the mean binocular DCIVA at 66 cm under photopic conditions 3 months after cataract surgery, in a series of patients, who previously underwent myopic laser surgery, bilaterally implanted with the non…

Re-evaluation of the muscle-full effect during continuously elevated amino acid availability in healthy young males

To assess muscle protein synthesis rates to continuous, elevated plasma amino acid availability in healthy young males

Effect of a neoprene wetsuit on pulmonary function

To establish whether the decrease in pulmonary function as a result of wearing a neoprene suit is caused by restriction or obstruction, and which effect is has on pulmonary volumes.

A study of the effects of balanced shoulder therapy on shoulder function, local fatigue and pain symptoms in children with FSHD type 1

Primary: To describe shoulder function, local fatigue and pain symptoms around the shoulders in children with FSHD type 1, before and after balanced shoulder therapy. Secondary: To gain insight into the experience of children and parents and the…

68Ga-PSMA-PET/CT and genomic alterations for future selection of patients with metastatic castration resistant prostate cancer (mCRPC) for Radium-223 treatment.

Primary Objective: • To determine the clinical Progression Free Survival (cPFS) in our study cohort of patients with mCRPC and 68Ga-PSMA-PET/CT selected bone-only disease (PET-bone only group). The cPFS will be compared to the cPFS of patients with…

Navigation for percutaneous liver ablation

The primary aim of this study is to assess the feasibility of EM-navigation for percutaneous liver ablation.

*improving outcome of patients with squamous cell ESophageal CArcinoma by dose escaLATion using high-prEcision mr-guided radiotherapy (ESCALATE): a phase 1 dose finding trial*

The main objective of this study is to determine the maximum tolerated dose (MTD) of 2-fraction boost MRI-guided radiotherapy (MRgRT) for patients with SCC following CROSS therapy. The secondary objectives are feasibility, non-dose limiting toxicity…

The ICU-Recover Box: using smart technology for monitoring health status after ICU admission Pilot study 2.0

This study aims to determine feasibility of providing and following ICU discharged patient with smart technology for 3 months after hospital discharge from a general ward of the Leiden UniversityMedical Centre. If proven successful, home monitoring…

Auricular vagal nerve stimulation combined with rehabilitation to enhance functional outcome in cerebral palsy patients with upper extremity deficits (AVANS study) Part1

The ultimate goal is to investigate whether aVNS can enhance cortical plasticity and improve functional outcomes during intensive rehabilitation programs in children with cerebral palsy. First, we aim to establish the extent of cortical plasticity…

WalkWell Gait reTrainer: Remote patient monitoring and gait retraining for knee OA

Our objective is to design and evaluate proof-of-concept of the WalkWell Gait reTrainer, an affordable, user-friendly continuous gait feedback system, complete with remote patient monitoring capabilities to support clinical care. We hypothesize that…

Ultralong-segment Barrett*s esophagus: towards a capsule-sponge surveillance strategy (ULSBE-Endosign study).

The primary objective is to investigate the concordance between the Endosign test and EGD by an expert endoscopist for detecting dysplasia and/or EAC in a high-risk category of ULSBE patients. Secondary objectives are to determine the acceptability…

oxIdative stress in late preterM and term newborns with Persistent pulmonAry hypertension in the neonatal intensive Care uniT (IMPACT-study)

To investigate oxidative stress levels in the plasma and urine of late preterm and term newborns treated for PPHN in the NICU.

Atrial Fibrillation Ablation and Autonomic Modulation via Thoracoscopic Surgery, 10 year follow up.

Primary Objective:The study aims to assess freedom from AF ten years after the procedure without the use of antiarrhythmic drugs in patients who underwent thoracoscopic ablation in advanced AF with or without GP ablation. Secondary Objectives:1. To…

Robot-assisted versus open extended lateral pancreaticojejunostomy for the treatment of symptomatic chronic pancreatitis (PANACOTTA): a multicenter patient- and assessor-blinded randomized trial

To assess the post-operative quality of recovery after robot-assisted as compared to open extended lateral pancreaticojejunostomy.