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Mindfulness training versus treatment as usual in adults with attention deficit hyperactivity disorder (ADHD)

To examine the (cost)effectiveness of mindfulness versus treatment as usual (TAU) in adults with Attention Deficit Hyperactivity Disorder (ADHD).

PVAI alone vs. PVAI plus ablation of complex fractionated atrial electrograms in a specific area of the left atrium in patients suffering from (longstanding) persistent atrial fibrillation.

The aim of this study is to determine if adding ablation restricted to specific areas of the left atrium to PVAI is superior to the standard care PVAI alone.

Treatment of Targeted Therapy-Related Fatigue in Patients with CML or GIST: A Single-Case Experimental Design

To investigate the efficacy of cognitive behaviour therapy (CBT) on reducing TTF in patients receiving TKIs for CML or GIST.

The effects of music therapy on expressive and communicative skills in relation to change in behavioral problems for patients with Huntington's Disease

Research questions:1. Does music therapy improve the expressive and communicative skills of patients with HD due to (specific) music therapy treatment? 2. Does music therapy change problem behavior of patients with HD?

Changes in incretines and bile acids after Roux-en-Y Gastric Bypass.

1. comparison between pre- and postoperative serum levels incretines and bile acids (after RYGB).2. comparison between S-RYGB and LBPL-RYGB with respect to incretines and bile acids.

A Phase 3, Multicenter, Randomized, Double-blind Study to Determine the Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects with Mild to Moderate Ulcerative Colitis, in both Acute and Maintenance Phases

Primary: The primary objective of the Double-blind Acute Phase of the study is to assess clinical response to MMX mesalamine/mesalazine between a low and high dose in children and adolescents aged 5-17 years with mild to moderate UC.The primary…

PRP injections in disci

Researching if the injection of PRP with patients suffering from discogenic low back problems with or without anular tear, without modic has significant beneficial effects on pain and functionality.

10-day decitabine versus conventional chemotherapy (*3+7*) followed by allografting in AML patients >= 60 years: a randomized phase III study of the EORTC Leukemia Group, CELG, GIMEMA and German MDS Study Group

The primary objective of this study is to compare, in a randomized phase III trial, the effect of 10-day decitabine at a dose of 20 mg/m2 versus conventional induction chemotherapy (*3+7*) on OS in older AML patients.

Cochlear Implantaton for siNGLE-sided seafness

The objectives of this study are to evaluate the clinical outcome of a cochlear implant (CI) over standard health care therapy with either BAHA or CROSS in patients with SSD and to examine the cost efficiency of cochlear implantation in these…

A Randomised, Double-Blind Study to Assess the Efficacy of Selumetinib
(AZD6244, Hyd-Sulfate) in Combination with Dacarbazine Compared with
Placebo in Combination with Dacarbazine as First Systemic Therapy in
Patients with Metastatic Uveal Melanoma (SUMIT)

ObjectivesPrimary objective1. To assess the efficacy of selumetinib in combination with dacarbazine compared with placebo in combination with dacarbazine in terms of Progression Free Survival (PFS) assessed by blinded independent central review (…

A Phase I, Open-Label, Non-Randomised, Multicentre Study to Assess the Effect of Rifampicin (a CYP3A4 Inducer) on the Pharmacokinetics of AZD9291 in Patients with EGFRm Positive NSCLC whose disease has Progressed on an EGFR TKI

To investigate the effect of a CYP3A4 inducer (rifampicin) on the PK of AZD9291.

Development of Targeted Antibody Therapy to Reduce Antimicrobial Resistance-Related Morbidity and Mortality in the Erasmus Medical Centre

To identify and clone antibodies that can neutralize the bacterial pathogens Escherichia coli and Pseudomonas aeruginosa.

Bone Marrow Collection in Healthy Volunteers

The objective of this project is to collect fresh human bone marrow and to process this bone marrow to an intended product in a short time to enable the use of this product in the acute phase of a disease/disorder/lesion of the central nervous…

A randomised comparison of Eye Movement Desensitization and Reprocessing (EMDR), Narrative Exposure Therapy (KIDNET) and waiting list control in traumatized refugee children.

The study aims to answer the following research questions:1. How high/low are levels of symptomatology of depression and/or PTSD in traumatised refugee children in ASC?2. Do symptom levels decrease after a short-term trauma-focused intervention?3.…

Randomized Controlled Trial to evaluate the effect of a retractor sponge in postoperative hospital stay in laparoscopic colorectal surgery in patients with malignancy.

We study the efficacy of the retractor sponge in laparoscopic colorectal surgery to reduce hospital stay in patients operated for a malignancy. Secondary objectives are duration of surgery, blood-loss,use of diuretics as volume therapy (during…

A model-based RSA Randomized Control Trial to evaluate the stability of the cementless Taperloc hip stem in four different treatment groups.

Evaluate the safety and effectiveness of four cementless Taperloc versions: Taperloc Complete Reduced Distal and Taperloc Legacy Full Profile Reduced Distal compared to Taperloc Complete Full Profile and Taperloc Legacy Full Profile in primary THA.

A Phase II study of Selinexor (KPT-330) combined with bortezomib and dexamethasone (SVd) for induction and consolidation for patients with progressive or refractory Multiple Myeloma.

Part I: Evaluate the safety and tolerability of selinexor at 3 different dose levels in combination with bortezomib/dexamethasone & determine recommended dose level (RDL) of selinexor for Part IIPart II: Evaluate the efficacy of the…

INTENT: immunogenicity in patients failing response on anti-TNF
- phase 1: immunogenicity and pharmacokinetics in patients failing to respond to TNF inhibitors.
- phase 2: clinical effectiveness of subsequent TNF inhibitor treatment and predictive value of pharmacokinetics and immunogenicity.

1. To determine the proportion of patients developing anti-drug antibodies (ADA) detectable with an antigen binding test (ABT, radioimmunoassay) in patients experiencing inefficacy of their first TNF inhibitor treatment (phase 1).2. To study…

Less pain and more function with physiotherapy treatment of a frozen shoulder? "The cold facts": a randomized controlled trial.

To evaluate the difference in functional outcome, measured by the SPADI, after treatment of adhesive capsulitis with or without physiotherapy

The effect of Virtual Reality Exposure Therapy (VRET) on social participation in people with a psychotic disorder: a multi-site randomized controlled trial.

The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…