87 results
To examine the effect of BCG vaccination on the composition and function of the bone marrow.
The main objective of this study is to investigate the effectiveness of the humeral immune response after influenza revaccination in patients with MG with acetylcholine antibodies (AChR MG). The secondary objectives are to determine if vaccination…
The primary objectives of this study in healthy subjects are:- To investigate the safety and tolerability of JNJ-61393215 versus placebo after single oral dose administration under fasted (ascending dose levels) and fed condition.- To characterize…
To determine the mechanism of action of propranolol in the prophylactic treatment of migraine.
Primary ObjectiveEstimate the proportion of subjects fulfilling criteria for symptomatic remission (as defined by Andreasen et al.)* following a transition to 12 months* treatment with flexible-dose PP3M in subjects with schizophrenia previously…
To determine the mechanisms underlying motor skill training, somatosensory electrical stimulation, and a combined intervention on motor skill acquisition, motor memory consolidation, and interlimb transfer in healthy younger and older adults.
The aim of the study is to compare the radiological outcome of three different biocomposite interference screws (BIS) in two different ACL-reconstruction techniques with reference to TW, absorption and clinical follow up after three years.
This study has been transitioned to CTIS with ID 2024-518684-35-00 check the CTIS register for the current data. The current project proposal continues on our findings of the performed prospective cohort study, aiming to develop a biomarker guided…
Studies examining the effect of couple therapy or couple-based interventions in treatment for personality disorder are very scarce and more research is required. Therefore, the present study examines the effect of couple-based interventions in…
Efficacy and safety trial with S 44819 after recent ischemic cerebral Event
The main aim of the ZELF-i project is to investigate the effectiveness of self-monitoring and personalized feedback as an add-on tool in the treatment of depression. By starting directly after intake, patients can make the most out of the usual…
- Investigate the safety and tolerability of single ascending doses of DNL104 in healthy volunteers.- Characterize the pharmacokinetics of DNL104 in plasma, CSF, and urine.- Characterize the effect of a high fat meal on the pharmacokinetics of…
To gain insight in the pharmacokinetics of sinecathechins ointment 10% (Veregen) applied on healthy skin, using Raman micro-spectroscopy and chromatography of tape strips.
Primary Objective: To investigate the effect of food order on postprandial blood glucose levels in children with type 1 diabetes, using 2 isocaloric meals. A standard meal with all macronutrients (carbohydrates, proteins and fat) combined will be…
To investigate the predictive factors for sarcopenia in high risk surgical oncological patients undergoing a CRS + HIPEC procedure. The secondary goal is to investigate the predictive factors for malabsorption and the incidence of anastomic leakage…
Primary objective:-To investigate the safety and tolerability of JNJ-54175446 in subjects with major depressive disorder.Secondary objectives:-Investigate the effect of JNJ-54175446 versus placebo on total sleep deprivation-induced changes in…
Feasibility of exoskeleton training for home use for patient with motor complete spinal cord injury.
In the present study, the feasibility of a training program with an exoskeleton for home use for people with motor complete SCI (ASIA A and B) will be examined. Participant will also be evaluated based on individual goal setting, patient…
Objectives: For patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) enrolled in this study, the objectives are as follows:Primary: -To assess the efficacy of bardoxolone methyl relative to placebo.Secondary…
The primary objective of the present study is to determine the effects of the `strength ventilation` breathing technique and exposure to cold, both separately and in combination, on the inflammatory response during human endotoxemia. To this end, we…
The purpose of the study is to investigate how quickly and to what extent JNJ-53718678 is absorbed, distributed, metabolized (broken down) and eliminated from the body. JNJ-53718678 to be administered will be labeled with 14-Carbon (14C) and is thus…