72 results
Primary objectives: - To evaluate the toxicity and feasibility of a preemptive minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination.- To evaluate the effect of a minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination on…
To assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer*s disease-causing mutation by determining if treatment with the study drug slows the rate of progression…
To study the effect size of FMT after a 3 weeks course of budesonide as induction therapy in patients with active ulcerative colitis despite previous therapy. The purpose of the pre-treatment is to reduce active inflammation prior to donor feces…
Effect of hyperbaric oxygen therapy (HBOT) on patients with chronic neurological deficiency due to stroke.
The primary objective is to measure the level of clinical improvement and quality of life at 6, 12 and 18 months. The secondary objective is to measure functional repair using MRI at 6 and 18 months postoperative. Other important objectives are…
The primary objective of this study is to evaluate the proportion of patients achieving FXI inhibition * 80% at trough (Day 91) after monthly dosing at 3 dose levels of MAA868.
The main objective of this study is to assess the safety, efficiency, and quality of the steerable punch for future CE-marking
The primary objective of this study is to show equivalence of the total pathological complete response rate (tpCR) in patients treated withHD201 plus chemotherapy to that in patients treated with Herceptin® plus chemotherapy. tpCR will be assessed…
To compare the effect of radioactive Iodine or hemithyroidectomy on the symptoms and quality of life (QoL) of patients with a benign euthyroid goiter.
Primary: Part 1: Safety and tolerability. Determine the MTD and/or RP2D of MAK683.Part 2: Anti-tumor activity of MAK683.Secondary: Part 1: Anti-tumor activity. Pharmacodynamics (PD). Pharmacokinetics (PK).Part 2: Safety and tolerability. PK, PD.
Primary objective: To study the safety and tolerability of BIIB078 in adults with C9ORF72-ALS.Secondary objective: To study the pharmacokinetics (PK) profile of BIIB078.
To examine the feasibility and acceptability, and preliminary efficacy, of a new developed enhanced CBT (eCBT) for pediatric obsessive-compulsive disorder
The goal of this study is to assess the efficacy of single dose preoperative radiotherapy in patients with low risk breast cancer. In this context, efficacy is the proportion of patients achieving a pathologic complete response after single dose…
This study will evaluate the safety, efficacy, and pharmacokinetics of UTTR1147A compared with placebo and compared with vedolizumab in patients with moderate to severe ulcerative colitis (UC).
To assess the impact of FMT on detectable intestinal carriage (by stool culture) of VRE in a 12 month follow-up period.
To test whether the Emma-app and/or a financial incentive can improve therapy adherence, clinical disease outcomes and quality of life in adolescents and young adults with a chronic health condition.
Primary Objectives:* Identify the maximum tolerated dose (MTD) of oprozomib formulations in combination with pomalidomide and dexamethasone (OPomd) in subjects with relapsed or refractory multiple myeloma* Evaluate the safety and tolerability of the…
Primary Objectives: 1. Are there differences in bone density parameters (cortical and trabecular density) between patients who will be treated with bone grafting and patients who will not receive bone grafts after open wedge osteotomy and plate…
We plan to conduct a large, pragmatic, multicentre, randomised non-inferiority trial to determine whether the use of intraoperative dexamethasone, a widely used antiemetic in perioperative medicine, is associated with an unacceptable increased risk…
To gain insight into the effects of TAE on HCAs and their behavior post-embolisation.