130 results
Mortality will be lower in patients who do not smoke during treatment of non-small cell lung carcinoma with PD-L1-inhibitors compared to patients who smoke during their treatment with PD-L1-inhibitors.
To determine whether plaques in young patients with familial hypercholesterolemia (aged below 50 years) are susceptible to significant plaque regression with early, aggressive lipid lowering therapy (statins, ezetimibe and/or PCSK9) according to…
The primary aim of the study is to improve the oral cleanliness of young high caries active children by a HAPA-based intervention to improve the brushing behaviour of parents in their children. Therefore, the effect of the HAPA-based intervention is…
The primary aim of the project is to find evidence that perioperative reduction of anxiety and paincatastrophizing by means of internet-based cognitive behavioral therapy (i-CBT) reduces theprevalence and intensity of PPBCT and post-treatment…
The aim of this study is to investigate the (cost-)effectiveness of the 'In Balans' fall prevention program. We will research the effect of 'In Balans' on the number of falls, fall injuries, physical performance (including…
1. To compare the impact of a 12-month cardiac rehabilitation program (PRO-FIT) vs. an invasive approach including coronary angiography and subsequent coronary revascularization in stable angina pectoris patients on angina symptoms.2. To evaluate…
To investigate the effect of a cows-milk-based formula supplemented with synbiotics from t=0 to t=21, t=42 and t=84 days after amoxicillin or amoxicillin/clavulanic acid treatment in toddlers aged 1, 2 and 3 years old on: - change in proportion of…
Investigate whether continuous monitoring of physical activity with an activity tracker leads to an improvement in preoperative endurance in elderly people with colorectal cancer, compared to a standard preoperative route with prehabilitation.
1) to investigate if patients on chronic NOAC treatment are sufficiently anticoagulated without additional UFH during CAG/PCI, and 2) if this sufficient anticoagulation can be confirmed pre-procedure by a point-of-care test, and3) to investigate if…
Overall we aim for a more effective treatment of provoked vulvodynia with less relapse, taking into account the patients autonomy as an important key to long term cure. Primary outcome: Decrease of pain during (attempt to) penetration, measured by a…
The primary aim of this study is to examine the feasibility, usability, and acceptability of the educational care pathway for both patients and healthcare professionals. The secondary aim is to investigate the preliminary effects on patients*…
Phase 1 • Primary objective: to determine the safety and tolerability, including the attenuation phenotype of a novel late-arresting GAP, named GA2 parasite, administered by sequentially increasing numbers of mosquito bites.• Secondary objective: to…
The primary objective is to determine the bifidogenic effects of a 4-week intervention with one of four dietary supplements (Chondroitin sulfate, NOVELOSE® 3490, and Pea Fiber, and Lactium®) in IBS patients. The secondary objective is to determine…
To study the potential of the daily use of a mini-trampoline or metformin added to the NHG -guided lifestyle to cure early type 2 diabetes in overweight and obese patients. PICO research question. What is the effect of the mini-trampoline or…
Primary objectives: to evaluate the efficacy of three different single doses of PHA-022121 versus placebo in achieving angioedema symptom relief during acute attacks and the efficacy of prophylactic treatment with PHA-022121 versus placebo in…
The aim of the current study is to identify risk locations, precipitating factors and personal risk factors of railway suicides in order to support additional preventive measures. This study adheres to several research questions:- What are important…
This study has been transitioned to CTIS with ID 2023-504593-38-00 check the CTIS register for the current data. The aim of this trial is to infuse multiple doses of human 1st trimester liver-derived MSC for the treatment of severe OI to determine…
To investigate the effectiveness of a personalized multi-domain lifestyle intervention compared to online access to general lifestyle-related health information on cognitive performance in older adults at risk of cognitive decline. Cognitive…
The objective of the study is to clinically assess the safety and effectiveness of LIQOSEAL® as a means of reducing intra- as well as post-operative CSF leakage in patients undergoing elective cranial intradural surgery with a dural closure…
The first objective is to investigate who the PMSA are, what strategies and motives they use to approach minors online, what sexual activities they do on the Internet and whether they are satisfied with their (sexual) wellbeing. The second objective…