234 results
To compare the objective response rate between patients with metastatic non-small cell lung cancer characterized by PDL-1 TPS<50% and low cTML (<300 nonsynonymous mutations) and either actionable mutation, inactivating STK11 or KEAP1…
To investigate the effect of a daily sachet of probiotics for 12 weeks vs placebo on vitamin K status in renal transplant recipients.
To establish the performance of the idi-CGM system among persons with DM.
Primary objectives:- To assess the differences in resting state EEG frequency spectrum analysis between patients with neurodegenerative and patients with non-neurological causes of MCI.* Power in microvolts squared of resting stage EEG for different…
2. OBJECTIVESThe overarching goal of this proposal is to examine the feasibility and effectiveness of mobile-based screening for MDD. We combine validated screening and interventions for MDD with innovative outreach methods to maximize impact.…
This study examines a the role of four key ultra-high-risk criteria for personality disorders: interpersonal trauma, personality functioning, quality of social support system and subclinical features of borderline personality disorder. For two of…
2 OBJECTIVES2.1 Primary Objective: To address the existing knowledge gaps and advance our understanding of cognitive variability, the CODEC study aims to integrate experience sampling methods, longitudinal designs, deep phenotyping cohorts, and…
The aim of this study is to evaluate if a PPT can significantly decrease - or possibly prevent - the collapse of the trachea in newborns with EA and moderate or severe TM. Additionally, the study aims to determine whether the observed effect of PPT…
The aim of this observational and exploratory study is to describe the accuracy of gaze stabilization in the presence of abnormal vestibular and visual functions. Visually induced image movements are used as the basis for gaze stability for each…
The aim of this study is to establish the accuracy of Molecular Culture for prediciting the outcome of the traditional blood culture.
The purpose of this study is to identify a pathogenic or likely pathogenic variant in unresolved families with antithrombin deficiency.
The aim of this study is to compare the effect of twice daily MI-E to twice daily AS with MAC on increase of PECF in patients with SMA with weak cough over a period of 3 years.
Objective: To test if participants with autism engaging in a CBT-I based online guided intervention (i-Sleep Autism) will experience a significant reduction in insomnia symptoms and improved mental health outcomes compared to the control group (…
Primary Objective: • Compare the diagnostic performance of the low dose abdominal CT scan to the normal dose abdominal CT scan in diagnosing causes of abdominal pain.Secondary Objectives:• Compare the diagnostic performance of diagnosing internal…
Do the T-REX Twente precautions have a positive impact on the quality of life (MAcNew QLMI), level of physical activity, and reduction of fear of movement in heart patients after a total median sternotomy compared to the (current) standard…
Primary Objective: • To investigate the feasibility of utilizing PAI as a means of detecting the SLN in patients with melanoma or breast cancerSecondary Objective(s): • Determine the most effective wavelengths for detecting ICG in PAI• Investigate…
Main objective is to determine whether nerve excitability can detect drug-induced effects of Riluzole in yet treatment- naïve patients with ALS. Secondary objectives are to determine the correlation between the Riluzole plasma concentration levels…
Primary objective: To validate the new, non-invasive QP-CMR imaging, stress T1 mapping reactivity and OS-CMR imaging with breathing maneuvers against invasive gold standard FFR for detection of obstructive CAD.Secondary objectives: 1) To compare (…
We will measure correlations between serially measured MRI parameters (pretreatment and early during treatment) and therapy outcome (response, locoregional recurrence and overall survival) in patients with HNSCC undergoing chemoradiation (CRT)…
Therefore, the main purpose of this study is to investigate whether this online intervention can indeed help prevent suicide attempts. In addition, we want to examine whether the intervention affects thoughts of suicide, quality of life and broader…