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Prevention of breast cancer in high risk women by monitoring microrna expression in nipple aspirate fluid.

To establish biomarkers in nipple aspirate fluid, follow them in time and link them to breast cancer development at its earliest stage in women at high risk for breast cancer. Threshold values of biomarkers will be determined that point to a…

A Randomised Trial comparing Surveillance with Radio-Frequency Ablation of Barrett*s Esophagus with Low-Grade Dysplasia; the SURF-study

The purpose of this project is to perform a randomized trial comparing BARRX ablation with endoscopic surveillance for patients with a Barrett*s esophagus containing low-grade dysplasia. This study will also assess the effect of RFA ablation in…

A phase III, double-blind, randomized, controlled study to evaluate the safety, immunogenicity and efficacy of GlaxoSmithKline Biologicals* HPV 16/18 L1/AS04 vaccine administered intramuscularly according to a three-dose schedule (0, 1, 6 month) in healthy adult female subjects aged 26 years and above.

* To demonstrate efficacy of the candidate vaccine in the prevention of (1) persistent infection (6-month definition) with HPV-16 or HPV-18 (by polymerase chain reaction [PCR]) and/or (2) histopathologically-confirmed CIN1+ associated with HPV-16 or…

Improving mobility in diabetic patients through resistance training

The objective of this study is to develop a resistance training intervention that improves mobility and quality of life in diabetic patients. It is also our intension to achieve a better understanding of the relation between diabetic neuropathy and…

Protocol CKI-302 KW-3902IV in the treatment of subjects with acute heart failure syndrome
A multicenter, randomized, double-blind, placebo-controlled study of the effects of KW-3902 injectable emulsion on heart failure signs and symptoms and renal function in subjects with acute heart failure syndrome and renal impairment who are hospitalized for volume overload and require intravenous diuretic therapy

To evaluate the effect of KW-3902IV in addition to IV loop diuretic therapy on heart failure signs and symptoms, persistent renal dysfunction, morbidity and mortality, and safety in subjects hospitalized with acute heart failure syndrome, volume…

Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists

To quantify the impact of outpatient nurse-led prevention clinics on the risk of future clinical events in patients with symptomatic coronary artery disease.

A twelve-month, multicenter, randomized, open-label study of safety, tolerability and efficacy of Certican-based regimen versus calcineurin inhibitor-based regimen in de novo liver transplant recipient

The study is designed to show that Certican® initiation together with reduction and thereafter discontinuation of calcineurin inhibitor (CNI) will improve significantly renal function in de novo liver transplant recipients as compared to…

Risk Education: Effect on Acceptance of Cardiovascular risk lowering Treatment In Primary care.

In this trial, current usual care concerning cardiovascular education is described. Second aim is to study what is understood of this education by the patient. Last aim is to study what effect training of GP's on this subject will have on the…

A randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Escalation and Dose-Confirmation Study to Evaluate the Safety and Efficacy of Rivaroxaban in Combination with Aspirin Alone or with Aspirin and a Thienopyridine in Subjects with Acute Coronary Syndromes

There are two phases in this trial with 2 objectives:In phase I of the trial it will be assessed which dose of rivaroxaban is the most safe and effective (most optimal benefit:risk profile). In phase II this dose will be further investigated to…

LIMIT: Lowering the Incidence of vascular complications with Metformin in patients with Impaired glucose tolerance and a recent TIA or minor ischemic stroke: a phase 2, randomized, controlled trial

To examine the safety, tolerability, and effect on glucose metabolism of metformin treatment in non-diabetic patients with TIA or minor ischemic stroke and impaired glucose tolerance.

Effects of post-operative topical steroid versus intraoperative subconjunctival steroid injection and postoperative miotic on intraocular inflammation following cataract extraction.

Primary Objective: Comparison of incidence of post-cataract extraction ocular inflammation with subconjunctival steroid injection versus traditional eye drops.Secondary Objective: Evaluation of usefulness of physostigmine following cataract surgery.

Prediction and Prevention of Posttraumatic Stress Disorder after Road Traffic Accidents in Children and Adolescents
Coping with Traumatic Events in Children and Adolescents

The objective is to investigate wether a brief CBT with parental involvement among children and adolescents with ASD reduces the risk of PTSD compared to a waitlist control group.

Influence of the dietary history in the prevention of coeliac disease : possibilities of induction of tolerance for gluten in genetically predisposed children. The dutch food intervention study

1. Development of a prevention strategy for CD in children from high risk families for the disease by induction of oral tolerance to gluten;2. Identification of the immunological mechanisms involved in initiating the aberrant response to gluten…

The Cardio Thoracic Harness

The objective of this study is to get insight in the effect of the Cardio Thoracic Harness for men and the Cardio thoracic bra for women. The harness and the bra possibly have an important role in pain management. The producer of the harness and the…

The influence of leucine supplementation and resistance training on body composition and muscle characteristics in healthy elderly.

In part A, we study the influence of ingestion of additional leucine on body composition, muscle function and plasma glucose responses.In part B, we study the influence of the timing of post-exercise protein intake on the effectiveness of the…

Dutch Indicated Prevention (DIP) of depression and anxiety in homes for the elderly

To evaluate the effects and costs of indicated prevention by a multicomponent, demand led stepped care programme, compared to usual care.

The effectiveness and cost-effectiveness of a proprioceptive balance board training programme for the prevention of recurrent acute lateral ankle sprains; a randomised control trial.

The proposed study evaluates the effect of a proprioceptive balance board training programme on ankle sprain recurrences that is applied to individual athletes after rehabilitation and treatment by usual care.

Autologous Platelet-Leukocyte Gel Therapy during sternum closure in cardiac surgery patients at risk for post-operative infection.

To investigate whether application of APLG will lead to reduction in: 1) sternal wound infections 2) vessel harvest site infections 3) postoperative blood loss 4) postoperative pain

Pressure and Silicone treatment in Hypertrophic Scarring

The objective of our observational clinical trial is to quantify the apoptosisrates of fibroblasts and growth-factorchanges in hypertrophic (burn) scars treated with pressure and/or silicone therapy.

A Double-Blind, Randomized, Placebo-controlled Study of Two Different Schedules of Palifermin (Pre-and Post Chemotherapy and Pre-Chemotherapy only) for Reduction in Severity of Oral Mucositis in Subjects with Multiple Myeloma (MM) Receiving High Dose Melphalan followed by Autologous Peripheral Blood Stem Cell Transplantation (PBSCT)

The primary objective is to compare the efficacy of palifermin relative to placebo when given either pre-and post-high dose chemotherapy or pre-high dose chemotherapy only with regard to the severity of oral mucositis.