190 results
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
Primary Objective: To determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxisSecondary Objectives:• To determine the dose-dependent protective efficacy of NF135.C10 CPS-immunization against homologous…
By providing patients reliable information and daily checklists via an app, we aim to give the patient a tool to be involved in the management of the catheter use. In this way, inappropriate use should be better signaled and discouraged, and the…
We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…
This is the first study to create and investigate the effectiveness of a multi-component intervention protocol in students with sleep problems. The aim is that such an intervention, combining cognitive-behavioural therapy for insomnia, mindfulness,…
To evaluate the incidence of incisional hernias after stoma reversal after preventive mesh placement compared to no mesh placement. Secondly the incidence of parastomal hernias will be recorded and complications caused by preventive mesh placement…
Primary Objective: To determine the effects of balance training on the neural control of standing sway in healthy younger and older adults and see if the learned balance skills are retained. Secondary Objective: To determine if balance improvements…
To analyze the difference in fT>MIC at the target site and infection rate for a single dose of 1 and 2g of cefazolin.
1.3. Study Design Rationale The ATLAS-INH trial (ALN-AT3SC-003) is a multicenter, multinational, randomized, openlabel Phase 3 study designed to demonstrate the efficacy and safety of fitusiran in patients with haemophilia A or B with inhibitory…
The primary objective of the proposed study is to evaluate the effect of the high dose or L-arginine (3.0 gram) and a lower dose of L-arginine (1.5 gram) compared with a placebo supplement on postprandial vascular function, assessed by brachial…
To test whether stabilisation of preterm infants with PBCC using the Concord is at least as effective when compared to the standard approach using the standard resuscitation table.
To study the effect of TRH on opioid-induced respiratory depression in healthy volunteers.
The primary objective is to evaluate clinically the effectiveness of two oral probiotic strains, compared with a placebo-group, on the gingival health during a two-week wash-in phase followed by a two-week period refraining from oral hygiene and a…
The general objective of this study protocol is to add another follow-up measurement, round 7, to the Doetinchem cohort study, 5 years after round 6, and 30 years after round 1 This contributes to an infrastructure of data to tackle research…
The objective of the study is as follows: - The development of a protocol to provide the stepped care intervention "Raise your strengths" in primary care for patients with chronic somatic symptoms- To gain insight into the possible effects…
This study concerns a pilot implementation and evaluation of FAME. - It aims to provide an initial indication of the efficacy of FAME in families in two living conditions: asylum centers and family locations. It is hypothesized that FAME has a…
Primary Objective: 1. To assess the impact of Winclove CLEAR on the quality of life of female rUTI patients.Secondary Objectives: 2. To assess the impact of Winclove CLEAR on the incidence of UTI and the (associated) urinary microbiota composition…
The aim of this pilot is to get an impression of the feasibility and added value of administering deep sound waves to the body during (neo) adjuvant chemotherapy. In addition, we want to gain insight into whether or not complete completion of a…
The current study has two aims. Firstly, to investigate the effectiveness and cost-effectiveness of 8 weeks of the E-health program, Featback, in comparison to Featback with online support from an expert patient, online support from an expert…