Search for a trial

Effects of VERApamil versus metoprolol to prevent progression from Paroxysmal to persistent Atrial Fibrillation

We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.

PROphylactic Mesh to prevent Incisional hernias at the former Stoma Site: the PROMISS-trial

To evaluate the incidence of incisional hernias after stoma reversal after preventive mesh placement compared to no mesh placement. Secondly the incidence of parastomal hernias will be recorded and complications caused by preventive mesh placement…

TArget-Site Concentrations of prophylactic cefazolin in foot and Ankle surgery

To analyze the difference in fT>MIC at the target site and infection rate for a single dose of 1 and 2g of cefazolin.

A Phase 3 Study to Evaluate the Efficacy and Safety of Fitusiran in Patients with Hemophilia A or B, with Inhibitory Antibodies to Factor VIII or IX

1.3. Study Design Rationale The ATLAS-INH trial (ALN-AT3SC-003) is a multicenter, multinational, randomized, openlabel Phase 3 study designed to demonstrate the efficacy and safety of fitusiran in patients with haemophilia A or B with inhibitory…

Deep Sound Wave Therapy for the prevention of neuropathy in the treatment of colorectal and breast cancer with chemotherapy:
a pilot / feasibility study '

The aim of this pilot is to get an impression of the feasibility and added value of administering deep sound waves to the body during (neo) adjuvant chemotherapy. In addition, we want to gain insight into whether or not complete completion of a…

Understanding of glycemic response using contextual data and modeling * a pilot study

The primary goal is to obtain and investigate the added value of real-life high quality contextual data (e.g. food intake, physical activity, sleep, wellbeing) to understand and predict the fluctuations in individual glucose levels. The secondary…

AV-Node Stimulation to influence heart failure markers in Acutely Decompensated Heart Failure patients

The purpose of the research trial is to assess if heart failure markers and clinical end-points are influenced by 24 hours of AV-node stimulation (AVNS) in acutely decompensated heart failure (ADHF) patients.Primary Objective(s)The primary objective…

Medication Review in patients with Polypharmacy in primary care: Effects of the Clinical Rules Engine and the Outcome Prioritisation Tool on Patient and Clinical Outcomes: CRE-OPT study

In the proposed project we evaluate the potential benefits and feasibility of including (a) a decision support system, *Clinical Rules Engine* (CRE) and (b) patient preferences, using the *Outcome Prioritization Tool* (OPT) in a comprehensive…

ATLAS-PPX trial: an open-label, multinational, switching study to describe the efficacy and safety of fitusiran prophylaxis in patients with hemophilia A and B with inhibitory antibodies to factor VIII or IX previously receiving bypassing agent prophylaxis.

1.3. Study Design Rationale The ATLAS-PPX trial (ALN-AT3SC-009) is a multicenter, multinational, open-label Phase 3 switching study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B, with inhibitory…

Efficacy of ketamine on acute suicidality, a multicenter double blind randomized placebo-controlled trial
(Ketamine Trial Amsterdam, KETA)

The aim of this study is to find a directly applicable intervention for acutely suicidal patients, so that the risk of these patients committing suicide is substantially lowered, leading to fewer actual suicides. To this end we propose a randomized…

SafePass: A prospective, non-randomized, multi-center, open-label,
clinical investigation to assess the safety and technical performance of the Emboliner
embolic protection catheter.

The primary objectives are to evaluate preliminary data on the safety and performance of theEmboliner embolic protection catheter.Safety:Assess procedural safety risksPerformance:Assess the technical performance in conjunction with a TAVR procedure.

Phase 3b Study for Management of Ocular Side Effects in Subjects with EGFR-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414)

This exploratory study is designed to evaluate several depatuxizumab mafodotin-related OSE management strategies.The main objective of this trial is to estimate the percentage of subjects in each prophylactic treatment arm who require a change in…

A Randomized, Placebo-Controlled, Phase 2 Study of HB-101, a Bivalent Cytomegalovirus (CMV) Vaccine, in CMV-Seronegative Recipient (R-) Patients Awaiting Kidney Transplantation from Living CMV-Seropositive Donors (D+)

To assess the safety and reactogenicity of HB-101.To assess the immunogenicity of HB-101.

An Open-Label, Non-Investigational Product, Multi-Center, Lead-In Study To Evaluate At Least 6 Months Of Prospective Efficacy And Selected Safety Data Of Factor IX (FIX) Prophylaxis Replacement Therapy In The Usual Care Setting Of Moderately Severe To Severe Adult Hemophilia B Subjects (FIX:C*2%) Who Are Negative For Neutralizing Antibodies (Nab) To Adeno-Associated Virus Vector (Aav)-Spark100.

- Primary Objectives: To establish a minimum of 6 months of prospective efficacy data of FIX prophylaxis replacement therapy in the usual care setting of hemophilia B subjects, who are negative for NAb to AAV-Spark100.- Secondary Objectives:…