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Become Active in Beating osteoarthritiS (BABS): A randomized controlled trial on the effectiveness of a promotional campaign in improving the management of osteoarthritis and quality of care

An information campaign was developed targeting early-stage KHOA patients and healthcare professionals (HCPs) to optimise timing of referral to secondary care.

Omega-3 fatty acid supplementation and the recovery from anorexia nervosa and comorbid depressive and anxiety problems: a pilot study

To draw definite conclusions about the effectiveness of omega-3 PUFA supplementation in anorexia nervosa patients a double-blinded, placebo-controlled randomized controlled trial (RCT) with a substantial sample size should be conducted. Prior to…

Cast OFF-2: One versus four-five weeks of plaster cast immobilization for non-reduced distal radius fractures. A randomized stepped wedge design.

It is our hypothesis that one week of plaster cast treatment will give a better functional outcome score as Patient Rated Wrist Evaluation (PRWE) and a lower pain score at 6 weeks post injury and will be less costly as compared to the control group…

Resmon Pro Diary Pilot Study - Evaluation of Vivisol Service to remotely prevent COPD exacerbations

This pilot does not aim to demonstrate the effectiveness of the system. The effectiveness of the system has been demonstrated in the recently published study: Chromed study, a multi-center Randomized Controlled Study.This pilot aims to obtain…

Exploring the measurability of co-responsibility over time and in context, via design interventions

This study has a strong explorative and qualitative approach and set-up. Please note that the goal of the study is to further identify possible areas for innovation for professionals, patients and their partners. The aim for this study is NOT to…

A Phase 3 open-label, multicenter study of the safety, efficacy, and pharmacokinetics of intravenous recombinant coagulation Factor VIII Fc-von Willebrand Factor-XTEN fusion protein (rFVIIIFc-VWF-XTEN; BIVV001) in previously treated pediatric patients <12 years of age with severe hemophilia A

To evaluate the safety of BIVV001 in previously treated pediatric subjects with hemophilia A.

Aortic Dynamics after Endovascular Aorta Repair

Gaining information on the dynamics and shape of the stent graft and stented target vessels, and how these change over time will improve our understanding about the fixation and/or sealing of the stent graft, which may help in stent graft selection…

SmartCheck- Scoring Meets the ARt of Teamwork

Validate the presence and correlation of intraoperative modifiable risk factors for colorectal seam leaks.

Transmission and colonisation of pertussis among Dutch high-school adolescents.

This pilot study is designed to evaluate the feasibility of field activities and if necessary adjust the methods for the full-scale study. Primary Objective: to evaluate the recruitment, retention and compliance rates for a prospective cohort study…

Short-term combined acalabrutinib and venetoclax treatment of newly diagnosed patients with CLL at high risk of infection and/or early treatment, who do not fulfil IWCLL treatment criteria for treatment. A randomized study with extensive immune phenotyping.

This study has been transitioned to CTIS with ID 2024-511072-33-00 check the CTIS register for the current data. The aim is thereby to reduce the risk of serious infections and the need for regular CLL treatment.

A randomized clinical trial to evaluate the efficacy of polyethylene glycol vs psyllium fiber to prevent rebleeding in patients hospitalized with bleeding diverticular disease.

To evaluate the efficacy of laxatives (polyethylene glycol) versus supplementation of fibers on the incidence of rebleeding in patients hospitalized for colonic diverticular bleeding.

Prediction of REsPonse to Antipsychotics using electRoEncephalography

The aim of this study is to validate EEG prediction markers of antipsychotic treatment outcome in patients with psychosis. *

Nervus X- Atrial Fibrillation trial (NX-AF)

The primary objective is to examine the impact of t-LLVS on electrophysiological properties of the atria and ventricles. Secondary objectives are:- to elucidate the correlation between proteostasis marker levels in serum and atrial tissue, and the…

Intensive Care Unit specific Virtual Reality for family members (ICU-VR-F) of patients in the ICU.

Our primary objective is to determine the effect of ICU-VR-F on symptoms of depression, anxiety and PTSD, and the health-related quality of life (HRQoL) in family members of ICU patients. The secondary objective is to determine the effect of ICU-VR-…

Impact of A2 milk versus conventional milk on intestinal health: a proof-of-concept study in Irritable Bowel Syndrome patients

This study will be done to gain insights in the effects of A2 milk on GI symptoms, and immune and defense parameters, in IBS patients. The information will gain more insights in the working mechanism of different types of beta-casein in individuals…

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Atogepant for the Prophylaxis of Migraine in Participants with Episodic Migraine Who Have Previously Failed 2 to 4 Classes of Oral Prophylactic Treatments (ELEVATE)

To prospectively test for superiority of atogepant 60 mg QD versus placebo for the prevention of migraine in participants with episodic migraine who have previously failed 2 to 4 classes of oral medications for the prophylaxis of migraine

The evaluation of the effects of a prebiotic mouth rinse on the oral ecosystem.

This study aims to evaluate the changes in microbial composition of the oral microbiome (main objective), changes in proportion of the red fluorescing plaque (RFP) and in gingival bleeding on marginal probing (BOMP) (secondary objectives) after…

Inhalation of Low Molecular Weight Heparins as a prophylaxis to prevent SARS-CoV-2 infection

1. Primary objective: - SARS-CoV-2 binding (expressed as concentration of virus bound in pg/mL) to epithelial cells isolated from nasal cavity between intervention and control groups (every volunteer is his own control group, depending on nostril).…

Modulation of the intestinal microbiome, and its effects on endurance exercise capacity in moderately trained individuals

The primary objective of this study is to investigate the effect of a six-week period personalized food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults. Further, this study has…

Butyrate/hexanoate-enriched triglycerides for metabolic health

The objective of this project is to identify a well consumable butyrate/hexanoate-enriched oil that increase circulating SCFA levels and improves postprandial substrate metabolism. We will investigate the effects of acute intake of four different…