156 results
This is a two part proof of efficacy study of KAF156 as a causal prophylactic agent in malaria. Results will be used to guide dose selection for further development of KAF156 in patients.
1. To reduce the time required for pre-exposure rabies vaccination of military personnel2. To reduce costs of pre-exposure rabies vaccination of military personnel 3. To obtain a non-inferior immune response to a shortened, low-dosed scheme compared…
To compare the number of responders to vaccination with pneumococcal and conjugated Hib vaccine at different time points after last dose of rituximab, to investigate what the ideal moment of vaccination would be. Secondly to study the immune-…
The objective is to study the cost-effectiveness of an adapted version of an American course (developed at UCSF), the online 'Mothers and Babies' intervention (Dutch name: "Positief zwanger"), by comparing it to a no intervention…
1a. Compare fat endocrine function in obese fit versus obese unfit people under resting conditions and immediately after exercise.1b. Compare fat endocrine function in non-obese fit versus non-obese unfit people under resting conditions and…
To demonstrate that percutaneous flexor tenotomy is an effective way to treat poorly healing ulcers in diabetic patients with hammertoes. We want to measure this effect by determining the healing time, percentage healed wounds and decrease in size…
To investigate the feasibility of using L-PRP on anastomosis to prevent septic complications from occuring.
To compare the number of responders to vaccination with the influenza virus vaccine and pneumococcal vaccine at different time points in treatment cycle of lenalidomide. Secondly to study the immune-response to vaccination, during treatment with…
The objective of this study is to determine in vitro the rheologic and oxygen transport capacity of the washed blood processed by one of 3 different cell savers and to measure in vivo after retransfusion of this processed blood in the patient the…
Primary Objective: The primary objective is to assess the effects of the oral administration of a daily dose of 1000 mg polyphenol extract for 3 weeks on biochemical markers of leucocyte recruitment in patients with documented CAD. Secondary…
To compare the blood pressure lowering effect of thiazides against calcium channel blockers in CNI-induced hypertension.
Primary ObjectiveThe primary objective for this study is to compare the clinical efficacy of weekly abatacept in combination with methotrexate to methotrexate alone in achieving Remission, defined as SDAI less than or equal to 3, at Week 24.…
Primary Objective: To determine if spinal and cortical balance control mechanisms mediate the age-associated decline in balance skills. Secondary Objective: To determine the reliability of TMS and H-reflex measures in the soleus muscle in different…
Present and evaluate a novel monitoring system for 24/7 continuously monitoring of COPD patients, using cHealth technologies.
Primary Objective To compare tacrolimus dosing of the new Envarsus®-based immunosuppressive regimen with current clinical practice over 6 months following de novo renal transplantation in a real-life setting in different European Countries.…
The main objective of this study is to evaluate whether our protocol results in non-functional overreaching in athletes in a controlled and safe way
Main objectives:To determine differences in NeuroCart profiles in different sub-groups based on cognitive testing and CSF biomarker profiling (i.e. cognitively normal, pre-symptomatic AD, prodromal AD, MCI, mild AD).To characterize a cohort of…
1. To determine the efficacy of QPI-1002 to reduce the incidence and severity of delayed graft function in comparison to placebo in recipients of a donation after brain death (DBD) older donor kidney.2. To assess the safety and tolerability of QPI-…
To evaluate the safety, tolerability and immunogenicity of a Twincer®-administered dry powder influenza vaccine in healthy adults.
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.