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Effects and costs of a combined screening and treatment program
for elderly (aged 75 years and over) with depressive symptoms
in general practice

To study the effects and costs of a screening and treatment program for elderly with depressive symptoms in general practice.

Assessment of patients with PPI-refractory GORD: reflux monitoring with or without proton pump inhibitor?

Objective: To compare the yield of Symptom Association Probability with two approaches to investigate patients with PPI-resistant symptoms: 24-hour pH monitoring off PPI and 24-hour impedance monitoring on PPI.

New duplex criteria for in-stent re-stenosis in aotro iliac arteries.
a long term follow up duplex post stenting trial.

The aim of the proposed study will determine new duplex ultrasound velocity (DUS) criteria for reference/normal values and in-stent re-stenosis after aorto-iliac stenting.

Stability and variability of prosthetic walking: The relation between the variability and stability of the gait pattern of amputees.

In this study the differences in variability and stability of people walking with and without a limb prosthesis will be investigated. In addition, it will be studied which of the employed outcome measures will discriminate best between both groups.…

The role of MRI viability testing to decide on percutaneous coronary interventions strategies of complex coronary artery disease.

To evaluate the predictive value of different MRI techniques to establish viability to guide percutaneous interventions decisions in patients with complex coronary artery disease.

Imitation, sensitivity for cues, complementary and joint action of children and adolescents with autism spectrum disorder.

The aim of this study is to investigate the hypothesis that persons with ASS may be less capable of 'reading' the behavior of others and because of that they may be less capable of complying to others, leading to social and/or behavioral…

Use of the Tanita TBF-300M body composition analyser in children with cystic fibrosis and healthy controls: a validation study using air displacement plethysmography

To assess whether the Tanita body composition analyser - a simple non-invasive device to estimate body composition - can be used to estimate body fat% in children and adolescents with cystic fibrosis in cross-sectional and longitudinal studies.

Cerebrospinal fluid metabolites as marker for the severity of progressive post-hemorrhagic ventricular dilatation in preterm infants

1. Is the concentration of brain specific proteins in CSF higher in newborn who are treated after high threshold as compared to newborns who are treated after low threshold?2. Is there any relationship between the concentration of brain specific…

Brain imaging of language function in autistic spectrum disorders

The primary objective of this study is to identify the neural correlates of language functions and, in particular, abnormal pragmatic communication in autistic spectrum disorders.

Neuroinflammation in the pathogenesis and progression of Parkinson's disease

This study aims to show increased microglia activation in brain parts involved in PD pathology, comparing PD patients with age-matched healthy control subjects. To see whether microglia activation changes early in the course of Parkinson*s disease (…

Prenatal diagnosis: MLPA and/or karyotyping

The aim of this study is to evaluate the role of MLPA in a routine clinical setting for detecting firstly, DS and secondly, the most common chromosomal aberrations compared to TKT (gold standard) in prenatal diagnosis.Is diagnostic accuracy of the…

AURORA project: AGE and UKPDS Rejoined to Optimize Risk Assessment in diabetes type 2

The aim of the study is to assess the possible additive value of the AGE reader measurement in a group of hospital-controlled (high-risk) persons with type 2 DM.

Exercise training in patients with idiopathic Pulmonary Arterial Hypertension

1. Does exercise training improve muscle function and exercise tolerance in patients with IPAH?2. Does exercise training in IPAH result in morphological and biochemical changes of the quadriceps muscle?3. Does exercise training in IPAH result in…

Fetal arrhythmia and long-term outcome

To estimate the cardiologic and neuropsychologic long term outcome in children born after fetal arrhythmia.

Radiolabeled bevacizumab as a tracer of VEGF expression in patients with colorectal liver metastases

Evaluation of tumor localization of In-111 labeled bevacizumab and possible correlation with VEGF expression in patients with colorectal liver metastases.

FDG-PET for avoidance of futile neck dissections after non-surgical treatment of advanced head and neck cancer

To study the diagnostic accuracy of FDG PET and MRI as a function of time in the response monitoring and detection of residual lymph node metastases after non-surgical treatment of advanced head and neck cancer.

Changes of Effective Downstream Pressure (EDP) and Cerebral Perfusion Pressure (CPP) under influence of hypnotics and volatile narcotics. A prospective, randomised, double-blinded trial.

Until now there has been a lack of investigations regarding the power of anaesthetics on the EDP.We will measure changes of EDP, CPPedp and autoregulation in each studie.- Study 1 : thiopental (5mg/kg) versus propofol (2mg/kg), - Study 2: etomidate…

Evaluation of aortic elastic properties in the long-term follow-up of surgical and catheter interventional closure of the persistent ductus arteriosus

1. To identify the patients at risk for aortic aneurysms after PDA closure.We expect to find a decreased distensibility of the aorta in this subgroup of patients which will be examined by MRI. Besides the functional MRI study genetic testing of the…

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation

This study can be divided in two parts:1) an early asthma diagnosis in young children2) study of etiological factors in relation to the development The main objective of this study is an early diagnosis of astma by the use of non-invasive biomarkers…

Imaging the response of glioblastoma brain tumours to treatment with radiotherapy and chemotherapy by magnetic resonance and positron emission tomography.

The main objective of the study is to compare the diagnostic power of Magnetic Resonance Spectroscopy, Fluorothymidine Positron Emission Tomography and conventional MRI in measuring the response of glioblastoma to radiotherapy and chemotherapy.The…