253 results
The rationale of this study was to investigate the alteration of colonic motor patterns in the early postoperative stage and between patients with no or minor LARS-symptoms (LARS-score < 30) compared to patients experiencing major LARS…
The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…
Point of care testing with Fcal POCT will reduce substantial the referral rate of children with chronic GI symptoms to the paediatrician.
Identification of host biomarkers, being membrane bound proteins, on both neutrophils and CD64 expressing cells, that have discriminatory difference in concentrations.
The primary objective is to study whether the (early prototype) sensors are able to reliably measure the vital signs they are designed to record. The secondary objective is to determine the feasibility and user acceptance of the (early prototype)…
Primary ObjectiveSafety Lead-in* Evaluate the safety of a high-dose regimen of encorafenib + binimetinib combination therapy in patients with BRAFV600-mutant melanoma who have asymptomatic brain metastasisPhase 2If the high-dose regimen is…
To determine the accuracy of US for detecting disease activity in paediatric patients with IBD and to develop an easy-to-use and accurate US-activity index that can accelerate and improve clinical management by reducing the need for gastrointestinal…
The aim of this study is to evaluate whether the MyTAP can be used as a screening tool to predict treatment success with MAD therapy. This will be evaluated during a 3 month follow-up of the therapy.Secondly, we want to compare the patient…
The main goal of this study is to test the feasibility of two different operant conditioning methods to decrease hyperreflexia of children with CP/SP/HSP, using real-time visual feedback.
To evaluate the performance of an optimized glaucoma genetic risk score (GRS) by inviting genotyped individuals from the population-based Lifelines cohort for in-depth ophthalmic examinations.
The primary objective is to demonstrate proof of concept by exploring to what extent combinations of clinicipathological factors, multispectral magnetic resonance imaging (MRI), and liquid biopsies prior to, during and after completion of NAC, are…
The primary objective of this study is to investigate the clearance of 5-FU for the 4 most common DPYD gene variants compared to the clearance of 5-FU in DPYD wild-type patients. The secondary objectives of this study are to determine the toxicity…
We hypothesize that the CardioMEMS HF system will be safe and superior to standard care in improving the quality of life and health status in patients with chronic HF in the Netherlands. Additionally, we hypothesize the CardioMEMS HF system is cost-…
Identify markers predicting progression of fibrosis in treated autoimmune hepatitis patients
To examine the efficacy of targeting atrial fibrotic tissue during an ablation procedure in treating persistent AF.We will also examine the efficacy of the fibrosis-guided ablation on a number of secondary or exploratory outcomes including the…
To assess whether PSMA-PET/CT imaging can be used as a tool to select men for prostate biopsy, or otherwise is able to reduce the number of bothersome biopsy cores in those with an increased risk of aggressive prostate cancer*
We aim to validate a panel of plasma biomarkers and investigate volatile biomarkers that potentially allow early and accurate identification of acute intestinal ischemia in patients. Second, we aim to identify a volatile organic compound (VOC)…
Zie protocol, hoofdstuk 3 (Objectives)
This study has been transitioned to CTIS with ID 2022-500785-10-00 check the CTIS register for the current data. 1) To compare pembrolizumab plus enzalutamide versus placebo plus enzalutamide with respect to overall survival (OS)2) To compare…
The objective of this study is to evaluate the reliability of the Ablacon Electrographic Flow (EGF) algorithm technology (Ablamap® Software) to identify AF sources and guide ablation therapy in patients with persistent atrial fibrillation.