496 results
Hypothesis: gaseous signaling molecules influence placental vasomotor activity to compensate for hypoxemia. Metabolites of these vasoactive molecules can be found in the blood and urine and can indicate whether this (compensatory) mechanism is used…
This study aims at establishing the influence of sampling site on the variability of ACT measurement at the end of coronary angiography or PCI.
The objective of this study is to obtain physiological data on lung aeration during pulmonary transition in newborn infants.
This protocol is the next step in development of a reproducible technique for the quantification of CBF using simultaneous ultrasound at the internal carotid artery. We hypothesize that simultaneous measurement of the contrast signal in the internal…
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
To ascertain the hypothesis that T-cell inflammation in the vascular wall of an unruptured intracranial aneurysm can be accurately detected with 18F-IL2 PET (proof-of-concept).
Primary Objective: 1. Determine if assessment of mucosal and serological immunological characteristics in combination with clinical indicators of disease behaviour and response to therapy can identify immune-based phenotypes with implications for…
To establish whether or not DPD deficient patients suffer from an altered white blood cell homeostasis or function, in particular of B or T lymphocytes.
To unravel the cause(s) of the FH phenotype in patients with no mutations in well-established lipid genes (LDLR, APOB, PCSK9).
To compare accumulation of liver fat (as measured using CAP) and liver fibrosis (as measured using fibroscan) between patients with quiescent and active inflammatory bowel disease
With this research project we will investigate the relationship between SSRI concentration in the (pre)term neonate and clinical short and long term effects on the neonate after exposure to SSRI*s during pregnancy and lactation. Furthermore, the…
Determining the role of duplex ultrasound in patients with a clinical suspicion for temporal arteritis.Determing the sensitivity, specificity, negative predictive value and positive predictive value of duplex ultrasound in patients with a clinical…
Primary Objective: to determine if lactate can be continuously and reliably measured by microdialysis in subcutaneous tissue in healthy volunteers
The objectives of the study are twofold:1) Determination of the absolute values and variability of PSMA uptake in tumour tissue and in normal tissues, including muscles, liver, spleen, bone marrow2) Determination of the absolute values and…
To identify novel childhood osteosarcoma predisposing genes.
To assess and compare the gastric emptying rate and gut hormone levels between patients one year after standard RYGB (S-RYGB), B-RYGB and EP-RYGB.
To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.
The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…
Investigating the molecular and phenotypic differences of iPSCs established from skin fibroblasts of discordant MZ BWS twin pairs.
4.1 Primary• To estimate the Sensitivity and False Positive rate of OTL38 for malignancy detection during Near Infrared Imaging (NIR).• To assess the safety and tolerability of single intravenous doses of OTL384.2 Secondary• To assess the safety of…