476 results
We propose to conduct a study in patients with mild to moderate AD where a cholinergic challenge is given in a placebo-controlled, cross-over fashion, prior to onset of treatment with a CEI. Patients will be followed over a period of 6 months to…
The aim of this prospective study is 1) to evaluate the diagnostic efficacy of DBE in comparison to MRE as surveillance technique of the small-bowel in PJS patients, 2) to analyze patient burden and quality of life with DBE and MRE, and 3) to…
The main objective of this study is to determine the added value of NIR fluorescence imaging in patients with pancreatic cancer undergoing SL and to identify predictors for patients that may benefit from SL.
To determine the effect of a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized or unestablished heart failure in primary care as compared to care as usual.
Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…
This project examines their relative contribution using pupil dilatation and concentration cortisol and alpha amylase in saliva as objective measures of mental effort and questionnaires. Young and elderly normally hearing and hearing impaired…
To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…
Primary Objective: To study the arginine-NO metabolism during fracture healing and dysfunctional fracture healingSecondary Objective(s): To investigate if differences or decreased arginine and NO concentrations in bone healing form a prognostic…
To investigate whether high resolution multi-site epicardial mapping of the atria in patients with structural heart disease undergoing cardiac surgery can identify patients at risk for developing early post-operative atrial fibrillation. The…
The present research protocol aims at the development and implementation of a valid self-report instrument for suicidality amongadolescents. The instrument needs to be invariant for ethnicity and needs to register fluctuations in suicide risk and…
1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…
The present study will test 1) whether childmolesters (including childpornography downloaders) show ASD symptoms, like disturbances in recognizing other*s emotions, feelings, intentions and thoughts, lack of interpersonal skills empathy deficits and…
Primary- MRI: correlation between neovascularisation in carotid atherosclerotic plaque characteristics assessed by dynamic 3.0 Tesla MRI and carotid atherosclerotic plaque at histology. - CT: correlation between size of lipid-rich-necrotic-core in…
To investigate the dynamics of tumour hypoxia as assessed by 18F-FAZA PET/CT during and after chemoradiotherapy. To investigate the best strategy to deliver a boost dose to the hypoxic tumour areas. This strategy may be either a simultaneous boost (…
Primary goal of this study:1) To determin the percentage of structural damage caused by an ankle inversion trauma. 2) Investigate to which patient characteristics, anamnestic characteristics, physical examination and structural characteristics…
Treatment strategy in early HCC aims at the local removal of the tumor and represents a potentially curative treatment option (resection, liver transplantation, PEI, RFA, BT). Patients in intermediate and advanced stage of HCC receive treatment with…
To evaluate anatomical changes of tumor and organs at risk with MRI before and during radiation treatment.
Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…
The primary objective of this study is to evaluate the long-term safety and tolerability of LY2216684 administered once daily (QD) in the adjunctive treatment with a selective serotonin reuptake inhibitor (SSRI) for up to approximately 1 year in…
To compare discrimination ability for touch and temperature between subjects with Down*s syndrome and healthy controls. To compare thermal pain thresholds between subjects with Down*s syndrome and healthy controls