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Healthy volunteer studies for development of imaging techniques for motion management in MR-guided adaptive radiotherapy

Development of new imaging techniques for MR-guided motion management in the presence of respiratory motion

Basophil Activation Test cow's milk for replacement of the food challenge test

Determination of the (cost)effectiveness of the replacement of the expensive, risky and time-consuming food challenge test bythe Basophil Activation Test (BAT) for the diagnosis of an IgE-mediated cow*s milk allergy in children.

Exploring an alternative pre-operative sentinel lymph node mapping method using a Magnetic tracer and MRI for melanoma patients

The primary objective of this study is to evaluate the feasibility and diagnostic accuracy of pre-operative MRI scanning using SPIO compared to lymphoscintigraphy (LS) and single-photon emission computed tomography/computed tomography (SPECT/CT)…

Multi-parametric MRI in patients suspected for muscle invasive bladder cancer: a new local staging paradigm

The aim of this study is to determine whether multiparametric MRI (mpMRI) of the bladder, in combination with an outpatient biopsy for histological confirmation, is a faster, safer, cheaper and therefore more cost-effective way to detect or…

Clinical performance study protocol for use of the B7-H4 (A57.1) Assay to identify and select B7-H4 positive ovarian, endometrial, biliary tract, breast cancer, and squamous non-small cell lung cancer patients for recruitment into the AstraZeneca Phase I/IIa Multi-center, Open-label Master Protocol Dose Escalation and Expansion Study of AZD8205 as Monotherapy and in Combination with Anticancer Agents in Participants with Advanced Solid Tumors

The primary objective of this clinical performance study is to evaluate the effectiveness of the B7-H4 (A57.1) Assay in identifying B7-H4 positive (B7-H4 membrane staining at any intensity in ≥25% tumor cells) ovarian, endometrial, biliary tract,…

Adequately Diagnosing Total Knee Arthroplasty Loosening: a Randomized Controlled Trial Evaluating the AtMoves Knee System in a Routine Clinical Setting

The primary objective of this study is to evaluate the efficacy of the AtMoves Knee System in the clinical diagnostic process of aseptic knee loosening in knee prostheses. This will be measured by the number of *failed outcomes* resulting from…

Pre-Symptomatic Detection of Impending Decompensation in Heart Failure through Voice Data (PRE-DETECT-HF)

The main objective of the study is to optimize the use and user-friendliness of the voice analysis program, which could potentially help with the early detection of acute deterioration in heart failure. Hopefully, we can develop a technique that…

Clinical evaluation of pre-hospital stroke triage devices- Electroencephalography

Primary objective: 1. To validate the data quality and diagnostic accuracy of StrokePointer to detect LVO stroke among patients with a suspected stroke in the pre-hospital setting. Secondary objectives:1. To determine the user-…

An explorative study to assess novel measurement methods for evaluating speech and swallowing function in healthy volunteers and patients with tongue carcinoma (stage I-II)

The first part of the study aims to depict speech and swallowing function with 3D-dMRI in healthy volunteers to establish a set protocol for use in patients. The second part of the study will investigate if anatomical and functional differences in…

Sequential imaging for suspicion of Prostate cancer Reducing Overdiagnosis and Unnecessary biopsy with Timely diagnosis of significant cancer

The primary objectives of this study are to evaluate the safety and effectiveness of a novel diagnostic approach applying PSA-density and MRI-imaging-based monitoring, as opposed to immediate prostate biopsy, in men with an intermediate risk of…

Clinical Performance Study Protocol for Use of VENTANA PD-L1 (SP263)
CDx Assay in [redacted]

The objective of this study is to establish the clinical performance of VENTANA PD-L1 (SP263) CDx Assay as a companion diagnostic (CDx) for the identification of patients with NSCLC who may benefit from treatment with [redacted]. …