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Management of Atrial fibriLLation INcluding tailoring of anticoagulation in patients from primary care - ALL-IN

To evaluate whether integral AF treatment in primary care is non-inferior in terms of reducing all-cause mortality (primary outcome) and specific cardiac mortality and hospitalization and non-cardiac hospitalization (secondary outcomes), as compared…

A Randomized, Comparative Trial of Two Posterior Lamellar Keratoplasty Techniques.
Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UTDSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK).

To demonstrate that DMEK is superior to DSAEK with respect to VA.

Feedback Informed Treatment in child- and adolescent psychiatry. A randomized cluster controlled Intervention study

Objective: To test the hypotheses that Feedback Informed Treatment together with treatment as usual will show significant more improvement than treatment as usual alone.

Screening and treatment of psychological distress in colorectal cancer with metastasized disease: the TES-trial

We have developed the TES program, which involves Targeted selection and Enhanced care, delivered on the basis of Stepped care (TES). The primary study aim is to evaluate the effectiveness of the TES-program compared to usual care in reducing…

Societal participation with Boston Psychiatric Rehabilitation for
patients with severe mental illness: a cost effectiveness study

The main objective of the study is to gain insight into the cost-effectiveness of BPR compared to care as usual (CAU) for patients withSMI who have a wish for change in their societal participation. Research questions:1. Is BPR (cost-)effective…

Point-of-Care C-reactive protein to assist in primary care management of children with lower respiratory tract infection

Analyse costs and effects of point of care (POC) C-reactive protein (CRP) measurement in children with non-severe lower respiratory tract infection (LRTI) in primary care.

HbA1c lowering before surgery in poorly controlled diabetes mellitus; a pilot study

to study the feasibility of lowering HbA1c before elective surgery in patients with suboptimalpoorly controlled DM (HbA1c >7%/53 mmol/mol).

ENdometrial cancer SURvivors' follow-up carE (ENSURE): Less is more? Randomized controlled trial to evaluate patient satisfaction and cost-effectiveness of a reduced follow-up schedule

The aim of this study is to compare a reduced follow-up schedule of 4 visits among low-risk, early-stage endometrial cancer survivors, with the schedule according to the current Dutch guideline that includes 10 to 13 visits, on:Primary outcomes:1.…

Patient controlled analgesia i.v. with morphine versus continuous epidural analgesia with bupivacaïne and sufentanil as pain relief after caesarean section.

We would like to research wether there is a difference in time of mobilization between women getting iv PCA with Morphine (PCA)as opposed to women getting continuous epidural analgesia (CEA)with bupivacaine and sufentanil.We expect that the PCA will…

Advance Care Planning; an Innovative Palliative Care Intervention to Improve Quality of Life in Cancer Patients *a Multi-Centre Cluster Randomized Clinical Trial

We will investigate whether the Respecting Choices program will improve communication between patients and healthcare professionals, will improve the QOL and wellbeing of patients and their relatives, will reduce futile treatments and unnecessary…

eVita COPD; Patient Centered Care through eHealth Solutions

The main aim is to investigate clinical effects of different implementation methods of online supported self-management for COPD patients in primary care. Secondary objectives include effects on well-being, health care use and actual use of the…

CHOICE: CHOosing treatment together In Cancer at the End of life

We aim to test the effectiveness of a patient-targeted preparatory tool (*Gesprekswijzer*) and an oncologist-targeted communication skills training to enhance shared decision making in consultations about palliative systemic treatment. The primary…

Detecting and Diagnosing Atrial Fibrillation: enhanced case-finding in patients from general practice and evaluating three ways of irregular pulse detection. A cluster randomised trial with nested diagnostic studies

The study has two main objectives. The first objective is to estimate the extra yield in detected cases of AF in patients aged 65 years and over, using case finding. The second is to compare three methods to detect AF.

The SO-HIP study,
Effectiveness of sensor monitoring in an occupational therapy rehabilitation program for older persons after hip fracture: design of a three-arm stepped wedge cluster randomized trial

The primary objective is to study the effect of sensor monitoring embedded in an OT rehabilitation program for older persons after hip fracture on recovery of daily functioning, 6 months after the start of rehabilitation, as compared to coaching by…

Erasmus MC Care Innovation for a healthy pregnancy. Efficacy of "Smarter Pregnant", an interactive food and lifestyle program on the mobile phone.

Investigate whether the "Smarter Pregnant" intervention in comparison with four screenings with food- and lifestyle advising leads to an improvement in unhealthy food habits (vegetables, fruit, folic acid use) after 24 weeks intervention,…

HOMERUN
Initiation of HOme MEchanical ventilation at home in a selective group of patients with chronic hypercapnic Respiratory failUre in the Netherlands

Patients with chronic respiratory failure currently start their ventilatory support in hospital as stated in national guideline. However, as these patients are severely disabled, a stay at the hospital for several days is experienced by many as very…

The effects of a yoga-based stress reduction program on fatigue and quality of life in women with chemotherapy for breast cancer: a mono-centre, pragmatic, randomized clinical study

To investigate whether an adjunctive YBSR program added to standard care compared to standard care alone, can reduce:1.fatigue symptoms (primary objective)2.psychological distressand improve:3.health-related quality of life4.sense of coherence5.…

Effictiveness of the online self management training Reuma Uitgedaagd! for adults with a rheumatic disease

The objective is to study the effectiveness of the online self management training Reuma Uitgedaagd! voor adults with a rheumatic disease.

COPD coaching intervention Friesland

This study aims to investigate the process and outcome of the implementation of a coaching intervention in COPD care in the Friesland province.

An explorative study to assess the potential impact of the Incosense Smart in Envida

The aim of this study is to explore the potential impact of the Incosense Smart at the client, professional, care processes and organization.