255 results
We would like to eludicate the role of dopamine on glucose metabolism.
1. To determine demographic, clinical, and brain morphological and functional predictors for IST, and; 2. To examine their associations with the level of increase of seizure threshold (*ST) during the ECT course, as measured at every sixth ECT-…
Primary objectives:1. To analyze the exact pathogenic mutations in the TCOF1 gene in TCS 2. To determine the severity, prevalence, natural course within the cohort TCS patients and potential metabolic and physical effects of OSAS in TCSSecondary…
To investigate the relation between a known genetic variation in a set of selected genes involved in the recognition of microorganisms and inflammation and the frequency of respiratory tract infections in a group of children with DS.
In the current study this hypothesis will be tested by examining whether blood serotonin levels, which are indicative of central serotonin levels, differ between infatuated and non-infatuated individuals. Furthermore, it will be investigated whether…
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
This research project aims to investigate the interaction between systemic immune cells and cells from the glandular tissue of patients with Sjögren's syndrome and sicca syndrome. We hope to obtain more insight in the cause and persistence of…
To assess differences in brain activation during the AA task in participants with SAD.
We aim to investigate which part of the pulmonary vasculature, the obstructed or non-obstructed, is responsible for the pulmonary vasodilator response.
The current study is designed to test the hypothesis that the medulla in transplanted kidneys is still hypoxic at 1 day after transplantation using a non-invasive method: BOLD MRI.By studying two groups a comparison can be made between patients…
In this project the expression, glycosylation and sialylation of mucins will be determined in tissue specimens of salivary gland tumors and in parallel, in the saliva of patients with a salivary gland tumor to determine whether altered mucin…
The aims of this pilot study are to describe the nutritional status of a well-defined group of Dutch RTT girls with complete clinical, molecular and neurophysiological work-up (full description is presented in the section *study population*) and to…
The aim of this study is to improve insight in potentially genetic factors contributing to the development of pyloric stenosis.We aim to investigate the association of the COL3A1 gene and pyloric stenosis because of concrete signs in the existing…
To investigate whether patients with hemophilia A develop less coronary artery atherosclerosis as compared to non-hemophilic males.
The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.
The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…
To establish whether miRNA expression patterns in platelets, monocytes, plasma and endothelial cells differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
The primary objective of this proof of principle study is to determine the effect of levosimendan on the strength and endurance of the diaphragm in healthy subjects. The secondary objective is to gain insight in the neural activation and efficiency…
The aim of this study is to investigate whether exercise changes FVIII levels in patients with moderate and mild haemophilia.
The objective of the current study is two-fold. First, to identify the duration and severity of back pain in the elderly. Second, to identify possible predictive prognostic factors for developing chronic back pain.