159 results
Primary objective: To determine the characteristics of language, speech and motor functions in MCI due to AD, mild AD and moderate AD Secondary objective: To explore the association between language, speech and motor functions in MCI due to AD and…
To determine prospectively the correlation between in vitro patient-derived organoid response and progression-free survival.
We aim to define components which are critical for lysosomal homeostasis and are affected in CLN3 disease. To this end we will perform multi-omics analysis of lysosomes isolated from fresh peripheral white blood mononuclear cells (PBMCs) of…
The aim of this study is to evaluate the validity of various algorithms for gait bout detection and spatiotemporal measures with a 3-IMU based sensor set worn on the feet and lower back. If this algorithm can be validated, it can be used to obtain…
We aim to investigate language production and verbal episodic memory performance, as well as the respective associated neural (co-)organisation of the two systems observed post-surgery in people with left temporal epilepsy in comparison to healthy…
Primary Objective: To further develop and evaluate a personalised patient-centred surveillance programme including a feedback platform for patients after curative treatment for CRC in terms of health-related quality of life (HRQoL).The goal is for…
This study will provide insights into the role of gut microbes from the upper (saliva) and/or lower GI (rectal/faecal) microbiota in the occurrence of postoperative complications in patients with resectable pancreatic and periampullary presumed (pre…
This study aims to provide insights into the processes and key host immune and microbiota factors that determine the infection kinetics, transmission and development of immunity during such infections. Furthermore, this study will enable us to…
The primary aims of this study are therefore to 1) compare DmO2 derived via NIRS between young sedentary, young endurance-trained, older sedentary, and older endurance-trained subjects; 2) to compare non-invasive (i.e. with NIRS and 31phosphorous…
To assess the effects of anesthetics on local (cerebral) microvascular parameters in craniotomy patients. Secondary objective: To assess the effects of anesthetics on systemic (sublingual) microvascular parameters in craniotomy patients.
To investigate the effects of aPFC-SMC phase-coupled tACS on exposure for SAD.
To identify clinical and immunological parameters that predict the course of disease of non-tuberculous mycobacterial skin and soft tissue infections.
This clinical performance study will evaluate the effectiveness of the Ki 67 IHC MIB-1 pharmDx (Dako Omnis) to identify estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)- early breast cancer patients whose tumours score Ki-67…
Primary: To assess the effects of a 2-week preoperative vegan diet in comparison to an omnivorous diet on protein synthesis rates in Hoffa*s fat pad, synovium, bone, ligaments, menisci, and cartilage in older adults with knee osteoarthritis…
The primary objective is to identify what causes colchicine resistance in FMF. Additionally, we will try to identify potential interventions to overcome resistance
The primary objective of this study is to evaluate the performance of the Navigate Anti-AAV9 Antibody Assay using serum specimens in subjects with SMA in Novartis clinical studies COAV101B12301 *STEER* and COAV101B12302 *STRENGTH*.
Part 1To determine if certain sleep stages (wake, REM, N1, N2, N3), and relatively high or low melatonin and cortisol levels, respectively, are associated with an increased or decreased instantaneous risk of cluster headache attacks in patients with…
This study aims to examine the interactive effect of indoor air quality and temperature on human cognitive performance. The main research objective of this study is to examine how poor indoor air quality in terms of 900 ppm CO2 compared to 3,000 ppm…
The purposes of this study are to uncover- Which clinical and neuroradiological measures can be used to predict the (neuropsychological) outcome and progression of symptoms in children with CMS?We hope that the results will contribute to an overall…
To characterize the phenotype, function and gene expression profiles of immune cells and hepatocytes in blood and liver of patients with chronic hepatitis D.