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1. To validate the existing guidelines with prospective and retrospective data from this cohort by performing an upper endoscopy at baseline, one year after inclusion and subsequently every three years thereafter in order to assess the risk of…
Primary Objective: The primary objective of this study is to investigate the prevalence EPI in the advanced HF population Secondary Objectives: • To determine the association between exocrine pancreatic function and markers of HF• To determine the…
The primary objective is to test whether rhythmic somatosensory input (vibrotactile stimulation at tremor frequency) reduces tremor power of Parkinson*s tremor, as compared to other vibrotactile stimulation settings (continuous stimulation,…
The primary objective is to investigate the potential benefit of scheduled natural daylight exposure to improve glucose control in T2DM individuals and to unravel molecular mechanisms underlying effects of natural daylight on circadian clocks and (…
1) Our first aim is to determine the involvement of GALT (Peyer*s patches, mesenteric lymph nodes) and peripheral lymph nodes in the immune deregulation that is observed in IBD2) Our second aim is to understand the pathophysiological mechanisms in…
The primary objectives are to: (1) Examine whether emotional incongruence (i.e., the mismatch between self-reported emotion and observed emotion from facial expression) is more common in patients with FND than non-FND control groups (healthy…
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
The main objective of this study is to assess effectiveness of the COVID-19 vaccinations, based on humoral (anti-coronavirus antibody) immunity, in GCA and PMR patients. Other objectives are assessing antigen-specific cellular (T-cell) immune…
The aim of this study is to figure out which factors can predict the development of gout, in addition to hyperuricemia.
The primary objective of this study is to further discribe the natural course and clinical characteristic of infantile FSHD.The secondary objectives are: - To identify (epi)genetic and environmental disease modifying factors that contribute to…
The primary objective of this study is to establish molecular profiles in lower rectal biopsies as close to the internal fistula orifice tissue and fistula scrapings based on single cell RNA sequencing, cellular protein expression by CyTOF and…
To investigate the effects of hemarthrosis of the immune modulary properties of adipose stromal cells.
With this study, we want to gain insight in the SARS-CoV-2 specific immunity (T- and B-cell) of patients with congenital immune disorders. This will add to our knowledge on SARS-CoV-2 specific immunity, and on the immune capacity of the patients…
Primary objective:Investigate if a trained immunity profile in innate immune cells might be a mechanism of HIV elite control.Secondary objectives:1. Determine the immune phenotypes that distinguishes family members of HIV elite controllers from…
To examine the impact of RSV infection on the diversity of the upper respiratory tract microbiome, measured by the Shannon index.
The objective of the PoCoMiMo study is to compare the abundance, and hepatic clearance of microbiota-derived molecules in the portal venous circulation between patients suffering from a primary hepatic malignancy versus those with pancreatic cancer…
Objective: The main objective of our study is to examine whether we can use the IT (as determined by visual irritation grading scale after SLS patch test) to predict HS formation after reduction mammaplasties. The secondary objectives consist of…
The aim is to investigate whether it is feasible to perform a 12-weeks nutritional intervention study in NSCLC patients on PD-1 ICI, and to effectively assess their nutritional, immune, and microbial status, with the intention to use this…
The goal of this study is to obtain insight into possible differences in macrophage and monocyte populations in uncomplicated pregnancies and pregnancies complicated by FGR.
Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.