95 results
1. To identify immunological alterations in peripheral lymphoid/skin/synovial tissue of patients with psoriatic artritis and psoriasis2. To correlate these alterations with disease stage, prognosis, treatment response3. To compare immunological…
Primary Objective: To study alterations in microcirculatory oxygenation during exercise in patients with long-COVID in relation to clinical symptoms. Secondary Objectives: To study in patients with long-COVID compared to convalescent controls•…
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.
To determine whether a standardized exercise workload elicits a different response on 1) metabolites/cardiac biomarkers in the general circulation (measured by blood values), and 2) contraction patterns in local myocardium (measured by…
The primary objective is to determine if physical fatigability is present in infantile and young adult patients with FSHD.The secondary objectives are to determine if there is an association between fatigability ando Disease severityo Muscle…
Primary Objective: To identify disease (Parkinson*s disease) specific alterations in neural control of breathing by using respiratory neurophysiological techniques.
Objective: The main objective is to evaluate the monocyte phenotype of children with FH compared to normocholesterolemic controls and to explore the effect of statin treatment.
The current research project aims to improve the care of CABG patients, by a redefinition of PMI. In this research proposal, we focus on the diagnostic and clinical relevance of postoperative biomarker increases and will determine the association…
In this proposal, we therefore aim to characterize in detail the cutaneous B cell response in patients with isolated CLE (CLE only) and patients with systemic and cutaneous disease (SLE/CLE). Primary Objectives: 1. Characterize autoreactive B cells…
The primary objective of the study is to investigate if the VO2, Pressure Time Product, Work of Breathing and transpulmonary Pressure Swings predict weaning failure or extubation failure after een succesfull SBT.
Primary objectives:- To prospectively study and describe the aetiology, clinical management and clinical impact of atypical viral infections in immunocompromised patients in Europe- To assess the utility of metagenomics as a tool to support clinical…
The main objective of this study is to evaluate the effect of anti-fibrotic/anti-SSc therapies using a SSc organ-on-a-chip (OoC) model. The secondary objectives of the study are:- To engineer an advanced OoC device to model SSc that incorporates key…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
1. To examine whether there is an increase in (nigro)striatal dopaminergic functioning in individuals of West-African descent relative to those of Dutch descent (assessed in older participants with DAT SPECT and with NM-MRI in the entire sample). (…
The main objective of this proposal is to establish ex-vivo models of bronchial epithelial cells from children. Use of (1) epithelial organoid cultures derived from bronchial or nasal epithelial cells; and of (2) bronchial brushings; (3) nasal…