616 results
To study:The effect of treatment with PPAR-* agonists on clinical features of FPLD To compare the monocytic (M1/M2) phenotype (peripheral and adipose tissue) of patients with FPLD - to controls - before and after treatment with PPAR* agonists.To…
•To determine the effect of hyperglycemic dysregulation on sleep characteristics (duration and quality), in patients with DM1 'What are the effects of controlled hyperglycemia on sleep characteristics (sleep duration and/or quality) in patients…
Hypothetically, in patients with PBC or PSC the FGF-19 production or -response could be altered. The goal of this research is to study the FGF19 production after a standardized oral fat challenge and the effect of this FGF19 production on bile acid…
In this study, we will assess whether healthy and hypertensive subjects with high-normal serum CK display greater salt retention and vascular contractility, compared to those with low-normal serum CK.
To obtain more information on peripheral muscle properties that can account for the reduced exercise capacity in patients with PPS compared to healthy subjects, and to develop an alternative method for determining aerobic exercise capacity in…
To gain more insight into the pathogenetic processes involved in SS by analyzing the infiltrate and structural changes in salivary glands of SS patients and compare these findings to those in other (aspecific) inflammatory and non-inflammatory…
to measure peripheral insulin sensitivity and intramyocellular concentrations of different FA metabolites (ceramide, gangliosides, diacylglycerol and triacylglycerol) known to interfere with the insulin signalling cascade during infusion of…
This study that documents the changes in heart rate, muscle sympathetic nerve activity, stroke volume and systemic vascular resistance in response to supine and head up tilted carotid sinus massage in elderly subjects.
In this study, we will assess whether healthy men with high-normal serum CK display attenuated platelet aggregation, compared to those with low-normal serum CK.
The aim o this study is to examine the cause(s) of large increases in weight after lung transplantation; the effect of daily physical activity, daily food intake and resting energy expenditure will be investigated in COPD and lung fibrosis lung…
to evaluate progression of IMT in post-coarctectomy patients in 7 years follow up.
The goals of the proposed study are: (1) to further elucidate the relations between impulse control, motivational strength of drug cues, and brain activation patterns (using fMRI); (2) to examine the relative strength by which these processes are…
1.To relate activity of the HPA axis to OCD symptoms and prefrontal brain abnormalities, using plasma ACTH and urine cortisol measures.2. To examine the role of nucleus accumbens activity on changes in endogenous glucose production, energy…
To sess the relationship between cerebral perfusion and clinical findings (neurological and neuropsychological) in patients with sickle cell disease.To compare iamging fincdings in children with and without sickle cell disease.
The objective of the study is to map the changes in the composition of salivary proteins as a consequence of irradiation of the salivary glands, to study how the composition of oral microflora changes as a consequence of irradiation and whether it…
Do high plasma free fatty acids lower central serotonergic responsivity?
This project is the cross-sectional part of a large-scale longitudinal follow-up survey in patients with adult-onset asthma. The objective of this part of the survey is to define different phenotypes of adult onset asthma and to detect risk factors…
The aim of this study is to investigate the bilateral symmetry of the human wrist joint and its clinical applicability. The analysis of the bilateral symmetry of the wrist is of great clinical relevance. If there appears to be a high grade of…
1. To establish the prevalence and prognostic impact of HD-associated LV dysfunction; 2. To identify (clues to) mechanisms/ pathways that are pathophysiologically involved in HD-associated LV function.
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…