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Schizophrenia and Happiness

The aim of this study is to demonstrate the influence of a serious diagnosis like schizophrenia has happiness in relation to daily activities.

A Prospective, Nonrandomized, Noninterventional Study to Compare Nexfin CO-trek Cardiac Output with Thermodilution Cardiac Output

Demonstrate that noninvasive monitoring of cardiac output with the ccNexfin System is comparable to that with thermodilution cardiac output.

Effect of mild therapeutic hypothermia in post cardiac arrest patients on inflammatory response

We want to describe in detail the MTH-induced changes in pro- and anti-inflammatory markers in patients after CA. We further aim to evaluate the relation between neurological outcome and levels of pro- and anti-inflammatory markers.

Biomarkers for differentiation of Parkinson*s disease subtypes.

The main objective of this study is to detect potential biomarkers for the differentiation of PD and DLB and the differentiation of PD subtypes by using neuroimaging.

Perceptual learning of interrupted speech: a behavioural study

This research will explore how fast phonemic restoration of degraded speech can be learned. This will be done by training and testing normal-hearing listeners in several sessions with interrupted speech. We will also train a group of normal-hearing…

Central mechanisms of ejaculatory dysfunction: a multi-modal fMRI investigation

The aim of the proposed research is to assess, using multimodal fMRI, both functional (BOLD responses) and structural (white matter) cerebral characteristics of the human IELT. In turn, this could provide specific novel (neocortical) targets in the…

Optical biopsy to improve the diagnosis of kidney cancer: a prospective, observational, multicentre, in-vivo study.

To evaluate the accuracy and adverse events of combined use of minimal invasive optical coherence tomography (OCT) to differentiate normal tissue from (different types of) malignant tissue in kidneys.

Characterization of nociceptive perturbation and threshold tracking methods

The purpose of this study is to obtain information for the design of a method to measure the behaviour of the ascending and descending pathways of the nociceptive system.

Brain-Computer Interface based on Cortical Electrodes

The present protocol addresses these issues, with a systematic approach where we first assess optimal settings for BCI, and then test the quality of BCI application in adequately sized groups of subjects. The whole project is aimed at obtaining a…

Coordination and proprioception of the knee joint - validity and reliability of the Mr Cube measurement system

Objective of this study is to determine validity, test-retest reliability and discriminant ability of the Mr Cube system to assess coordination and proprioception of the knee joint in patients following ACL reconstruction, patients with patellar…

Prospective, randomized, open label trial of six vs. twelve months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction.

To test the hypothesis that 6 months DAPT after second generation DES implantation in STEMI is not inferior to 12 months DAPT in terms of clinical outcomes (composite endpoint of all-cause mortality, any MI, any revascularization, stroke and major…

IgG-subclass and/or antipolysaccharide antibody deficiency.

Primary: To provide insight in the prevalence of diagnosed cases of IgG-subclass and/or antipolysaccharide antibodydeficiency in Dutch children. Secondary: To provide insight in the diagnostic process, the clinical presentation, the therapies used…

Facilitation of human long-term memory with post-learning physical exercise

To examine the behavioural and neural effects of a single session of post-learning exercise on long-term memory retention in humans.

The effect of Alphabodies® against human lnterleukin lL23 in the transplant model of psoriasis, in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intradermally into the transplant.

Are Alphabodies against IL23 effecive in the transplant model of psoriasis

Mutations in thyroid hormone receptor alpha 2

The family with the TRα2 premature stop enables us to investigate the biological role of the orphan wild-type TRα2 and the consequences of its dysfunction. The primary objectives of this proposal are (i) to search for a biological function of TRα2…

Post-traumatic osteoarthritis and function after surgery of trimalleolar fractures: is the function on medium follow-up period predictive for the long term follow-up period?

Determination of post-traumatic osteoarthritis in patients with a short follow-up period after ankle-surgery.

Macroscopic and microscopic changes of a locally advanced rectal tumour during radiotherapy: assessment using anatomical, functional and cinematic MRI.

The purpose of this pilot study is twofold: - evaluation of the tumour movement and regression during and short after long course pre-operative therapy for locally advanced rectal cancer in order to develop an integrated or sequential dose…

Cardiac dysfunction and undiagnosed heart failure in women as a long term effect of the treatment of breast cancer in an unselected primary care setting

The aim of our study is to assess the prevalence of cardiac dysfunction and undiagnosed heart failure in women registered in general practice with a history of breast cancer who received chemotherapy and / or radiotherapy as compared to a matched…

The impact of adjuvant chemotherapy on health-related quality of life in elderly resected stage III colon cancer patients

The identify the health-related quality of life of elderly patients with resected stage III colon cancer and relate the outcomes to patient and treatment characteristics (surgery alone or surgery plus adjuvant chemotherapy). Furthermore, the impact…

The Body in Embodiment: Specifying the Role of Peripheral Input in Grounded Cognition

The goal of the planned studies is to determine the significance of afferent and efferent motor processes in facial expressions that may impact evaluative judgments or responses induced by linguistic and pictorial representations of facial…