126 results
The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…
Investigating the influence of Transcranial Magnetic Stimulation (TMS)-disruptions on the neural processes in the areas involved in the adaptation abilities of the human oculomotor system.
We will evaluate the acute effects of GH on, and its relation with, cognition in healthy subjects. The present proposal focuses on the following questions:1. Does an acute rise of plasma GH levels have a (beneficial) effect on cognitive performance…
Aim: 1) To continue studying (the determinants of) the decline in functioning in the domains neurological deficits, physical functioning, mental health, social functioning and general health in the first 9 years after the diagnosis, and 2) to study…
The primary objective of the present study is to increase our insight in the neural processing of speech in pre-lingually deaf CI patients regarding the prediction and explanation of postoperative differences in performance within this specific…
We propose to investigate the health related quality of life (HRQoL) in childhood survivors of refractory GvHD who have been treated with mesenchymal stem cell transfusions. This will be a multi center study involving the Division of Clinical…
To gain insight in the agreement and differences between patient and proxy respondents when assessing the health status of the patient en the factors that could be of influence.
In this study we will try to obtain the rise in value of fibrinogen concentrate infusion in combination with FFP vs FFP transfusion in surgery patients with massive peri-operative bleeding problems and cardiothoracic surgery patients after heart…
The primary objective of this study is to determine the prevalence of V-MRSA in areas with high density of pig farming compared to the expected prevalence of MRSA in the general population of The Netherlands and as a secondary objective to assess…
Perpetuating factors associated with long term disability due to mental disorders are unclear. More knowledge about these factors is needed for professionals in insurance, occupational and curative healthcare to identify high-risk groups, to prevent…
To determine the reproducibility for quantitative analysis of MRI with contrast en diffusion weighted MRI (DWI) if abdominal malignant tumors.
In this studie we wish to examine the FGF-23 suppressive effects of calcitonin in healthy men.
The objective of the current study is to determine whether cognitive, emotional, behavioural, and personality explain individual difference in fatigue symptomatology. Furthermore, this study wants to examine whether fatigue is a risk marker for…
The aim of the study is to evaluate the validity and reproducibility of the ambulatory system, containing IFS*s and IMS*s, with respect to a reference system, to measure the frontal knee moment during gait in patients with osteoarthritis. As a…
The primary objective is to examine whether vardenafil (a PDE-5 inhibitor) can improve the cognition of healthy young volunteers. Secondary, we will assess the effects of vardenafil on electrophysiological correlates of cognition.
How do a spatial shift of attention and an increased working memory load influence the dynamics of neural competition?
To determine whether glucose, lipid and protein metabolism can be accurately measured using stable isotopes in the same patient on two occasions in a 48 hour interval.
The main objective of this study is: • To determine the optimal site to position the left ventricular pacing lead for each individual patient with an ischemic Cardiomyopathy (CMP). The site is selected based on the latest mechanical activated site…
The development of a practical COPD disease severity index developed and validated in primary care settings and thus ready-for-use in primary care after completion of the proposed project.
The primary purpose is validation of the dutch version of a brief health-related quality of life (HRQOL) tool in children with systemic lupus erythematosus (SLE). This tool is called *Simple Measure of Impact of Lupus Erythematosus in Youngsters© (…