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A randomized-controlled trial investigating the effects of a magic-based intervention in children undergoing catheter-based ablation.

The primary objective is to investigate the efficacy of a magic-based intervention in alleviating short-term self-reported distress in children (7-18 years of age) undergoing catheter-based ablation for cardiac arrhythmias on the day of the…

Metabolic syndrome and vascular damage in relation to accelerated aging in survivors of hematopoietic stem cell transplantation for hematological malignancy.

To study in two national cohorts of HSCT survivors, treated in different time periods, the prevalence and risk factors of metabolic syndrome, endothelial dysfunction (as a sign of vascular damage) and the clinical phenotypes of accelerated aging so…

A Prospective, Observational, Basket, Comprehensive Cohort Study of Children and Adolescents Aged Less Than 18 Years with Anemia Associated with Chronic Kidney Disease Requiring or Not Requiring Dialysis.

Primary:Evaluate the impact of SoC anemia management on Hgb concentrationsSecondary:- Characterize the use of ESA therapies in management of anemia associated with moderate to severe CKD in children and adolescents aged <18 years- Evaluate…

Evolution over time of exercise capacity in Tetralogy of Fallot, a follow up study of *TOFFIE* study participants

Primary Objective: - To determine the evolution over time of VO2peak, cardiac function, pulmonary function and muscle strength in children and adolescents with rToF and how these relate to each other and to quality of life.Secondary Objectives:- To…

*How do you Feelee?* Does an ordinary question a day supports youth in a forensic outpatient setting to become more emotional balanced?

The aim of the study is to gain more insight into the working factors of the Feelee app as a supportive tool to TAU in forensic outpatient settings. We examine whether the daily tracking of emotions by means of emojis together with the collected…

Dietary changes and markers of stress and depression in freshman bachelor students at Wageningen University

Our first primary research objective is to investigate if and how students are changing their diet toward a more plant-based diet. Our second primary objective is to assess changes in stress by using subjective methods (questionnaires) and a…

A 5-year Natural History Study in LAMA2-related muscular dystrophy and SELENON-related myopathy: the extended LAST STRONG Study

With the extended LAST STRONG Study, we aim to (1) collect 3-year and 5-year natural history data, (2) implement the natural history data collection into clinical care and international guidelines (reach trial readiness), and (3) do in-depth…

The Muscle Quality Index: linking quantitative MRI to muscle function

In this exploratory study we aim:1) To identify the confounding factors in qMRI analysis (e.g. age, gender, body composition)2) To determine the relation between qMRI parameters and muscle force and function taking into account the confounding…

Anterior cruciate ligament reconstruction in patients with open physis: risk for growth abnormalities and outcome

To determine the incidence of linear and angular growth disturbances following ACL reconstruction in patients with open physis.

Trial readiness and fitness for congenital myopathies: A 2-year prospective natural history study including a cross-sectional study on muscle fatigability

Part 1: Assess the natural disease course of three congenital myopathies during 24 months. This will enable us to obtain a detailed assessment of the phenotype and genotype, evaluate and optimize the current care, determine the rate of disease…

A multi-center, non-randomized study to characterize biomarkers in cerebrospinal fluid (CSF) of patients with infantile-onset (IOPD) or late-onset Pompe disease (LOPD)

To evaluate Hex4 concentrations in CSF from patients with infantile-onset (IOPD) and late-onset (LOPD) Pompe disease