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The impact of low level laser treatment on skeletal muscle and skin tissue mitochondrial respiration, metabolic activity and signaling in vivo in humans

Primary objective: To assess the impact of acute laser treatment on muscle tissue mitochondrial respiration in vivo in healthy, young adults. Secondary objective: To assess the impact of acute laser treatment on muscle cellular energy, anabolic,…

Biasing decision flexibility with thalamic ultrasound stimulation

Our primary objective is to elucidate the neural and cognitive effects of short-term TUS to two thalamic subdivisions in humans. To this end, we target two thalamic subregions that are spatially adjacent yet feature divergent connectivity profiles…

Evaluation of V*9Vδ2-T cells in the peripheral blood of patients with metastatic castrationresistant
prostate cancer

To investigate the frequency of V*9Vδ2-T cells in patients with metastatic castration-resistant prostate cancer

TNO post-COVID monitoring app for daily monitoring of symptoms, triggers and activities

With this study we want to test the user experience of the prototype app and to develop a method to identify subtypes of post-covid patients and link this to demografic, medical and sociopychological characteristics as predictors.

Assessment of mitochondrial function measurements in Parkinson's disease patients and healthy volunteers to identify new potential biomarkers.

The primary goal of this phase 0 study is to assess the variability of mitochondrial function measurements in healthy volunteers and PD patients.

Mechanical Analysis of function and Gait In total Knee replacements

The primary objective of this study is to determine the femorotibial and patellofemoral weight bearing in vivo kinematics of Journey II BCS TKA patients and to determine correlations that the kinematics may have with patient-reported outcome…

Validation of algorithms for imu-based gait bout detection and spatiotemporal measures in real-world activities

The aim of this study is to evaluate the validity of various algorithms for gait bout detection and spatiotemporal measures with a 3-IMU based sensor set worn on the feet and lower back. If this algorithm can be validated, it can be used to obtain…

Optimizing parasite transmission to laboratory-reared mosquitoes following controlled human malaria infection with Plasmodium vivax asexual blood stage parasites in malaria-naïve healthy volunteers in the Netherlands

Main objective: Develop a protocol to reproducibly infect mosquitoes with blood from human study participants undergoing asexual blood stage CHMI with the P. vivax clone PvW1.Secondary objectives: Maximize mosquito infection rate with PvW1 by I)…

Bioavailability of omega-3 fatty acids from fish oil supplements

To compare the plasma concentration versus time profiles and postprandial bioavailability of DHA and EPA after a nutritionally relevant oral dose of 1.1 gram (expressed as DHA + EPA) administered as either CCx gelatin-based soft chews (emulsified)…

BIO-006

Primary ObjectiveTo assess the safety, feasibility and frequency of relapsing P. vivax PvW1 infection after experimental sporozoite-administered Controlled Human Malaria Infection (CHMI)Secondary ObjectivesTo assess the immune response to primary…

Therapy adherence, errors in inhalation technique and usability of real-time feedback with the RS01X* in COPD patients: a pilot study

In this pilot study, the primary objectives we intend to investigate are: the effect real-time feedback has on 1) the type and 2) number of errors COPD patients make, 3) the therapy adherence of COPD patients while using the RS01X*, and 4) the…